Deuterolizin

Deuterolizin
Identifikatori
EC broj	3.4.24.39
CAS broj	247028-11-1
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Deuterolizin (EC 3.4.24.39, Penicillium roqueforti proteaza II, mikrobna neutralna proteinaza II, kiselinska metaloproteinaza, neutralna proteinaza II, Penicillium roqueforti metaloproteinaza) je enzim.^{[1][2][3][4][5]} Ovaj enzim katalizuje sledeću hemijsku reakciju

Preferentno razlaanje veza sa hidrofobnim ostacima u P1'; takođe Asn³-Gln i Gly⁸-Ser veza u lancu insulina B

Ovaj enzim je prisutan u Penicillium roqueforti, P. caseicolum, Aspergillus sojae i A. Oryzae.

Reference

1. Nakadai, T., Nasuno, S. and Iguchi, N. (1973). „Purification and properties of neutral proteinase II from Aspergillus oryzae”. Agric. Biol. Chem. 37: 2703-2708. 
2. Gripon, J.-C. and Hermier, J. (1974). „Le système protéolytique de Penicillium roqueforti. III. Purification, propriétés et spécificité d’une protéase inhibée par l’E.D.T.A”. Biochimie 56: 1324-1332. PMID 4219726. 
3. Sekine, H. (1976). „, Neutral proteinases I and II of Aspergillus sojae action on various substrates”. Agric. Biol. Chem. 40: 703-709. 
4. Gripon, J.C., Auberger, B. and Lenoir, J. (1980). „Metalloproteases from Penicillium caseicolum and P. roqueforti: comparision of specificity and chemical characterization”. Int. J. Biochem. 12: 451-455. PMID 6998789. 
5. Vaganova, T.I., Ivanova, N.M. and Stepanov, V.M. (1988). „Isolation and properties of the "acid" metalloproteinase from Aspergillus oryzae”. Biochemistry (Mosc) 53: 1171-1178. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Deuterolysin