Dekaprenilfosfo-beta-D-ribofuranoza 2-oksidaza

Dekaprenilfosfo-beta-D-ribofuranoza 2-oksidaza
Identifikatori
EC broj	1.1.98.3
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Dekaprenilfosfo-beta-D-ribofuranoza 2-oksidaza (EC 1.1.98.3, dekaprenilfosforil-beta-D-ribofuranozna 2'-epimeraza, Rv3790, DprE1) je enzim sa sistematskim imenom trans,oktacis-dekaprenilfosfo-beta-D-ribofuranoza:FAD 2-oksidoreduktaza.^[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju

trans,octacis-dekaprenilfosfo-beta-D-ribofuranoza + FAD ${\displaystyle \rightleftharpoons }$ trans,octacis-dekaprenilfosfo-beta-D-eritro-pentofuranozid-2-uloza + FADH₂

Ovaj enzim, izolovan iz bakterije Mycobakterija smegmatis, učestvuje zajedno sa EC 1.1.1.333, dekaprenilfosfo-D-eritro-pentofuranozid-2-uloza 2-reduktazom, u epimerizaciji trans,oktacis-dekaprenilfosfo-beta-D-ribofuranoz do trans,octacis-dekaprenilfosfo-beta-D-arabinofuranoze, arabinozilnog donora za biosintezu arabinanskih polimera mikobakterijskog ćelijskog zida.

Reference

1. Ribeiro, A.L., Degiacomi, G., Ewann, F., Buroni, S., Incandela, M.L., Chiarelli, L.R., Mori, G., Kim, J., Contreras-Dominguez, M., Park, Y.S., Han, S.J., Brodin, P., Valentini, G., Rizzi, M., Riccardi, G. and Pasca, M.R. (2011). „Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis”. PLoS One 6: #e26675-e26675. PMID 22069462. 
2. Trefzer, C., Škovierová, H., Buroni, S., Bobovská, A., Nenci, S., Molteni, E., Pojer, F., Pasca, M.R., Makarov, V., Cole, S.T., Riccardi, G., Mikušová, K. and Johnsson, K. (2012). „Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-D-ribofuranose 2′-oxidase DprE1”. J. Am. Chem. Soc. 134: 912-915. PMID 22188377. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Decaprenylphospho-beta-D-ribofuranose+2-oxidase