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Defosfo-(reduktaza kinaza) kinaza
Identifikatori
EC broj	2.7.11.3
CAS broj	72060-33-4
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Defosfo-(reduktaza kinaza) kinaza (EC 2.7.11.3, AMP-activirana kinaza, AMP-activirana proteinska kinaza kinaza, hidroksimetilglutaril koenzim A reduktaza kinaza kinaza, hidroksimetilglutaril koenzim A reduktaza kinaza kinaza (fosforilacija), reduktazna kinaza, reduktazna kinaza kinaza, STK30) je enzim sa sistematskim imenom ATP:defosfo(hidroksimetilglutaril-KoA reduktaza (NADPH)) kinaza} fosfotransferaza.^[1]^[2]^[3]^[4]^[5] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + defosfo[hidroksimetilglutaril-KoA reduktaza (NADPH)] kinaza}

\rightleftharpoons

ADP + {[hidroksimetilglutaril-KoA reduktaza (NADPH)] kinaza}

Ovaj enzim se aktivira AMP-om i specifičan je za svoj supstrat.

Reference

↑ Beg, Z.H., Stonik, J.A. and Brewer, H.B., Jr. (1979). „Characterization and regulation of reductase kinase, a protein kinase that modulates the enzymic activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase”. Proc. Natl. Acad. Sci. USA 76: 4375-4379. PMID 291971.
↑ Ingebritsen, T.S., Lee, H.-S., Parker, R.A. and Gibson, D.M. (1978). „Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation”. Biochem. Biophys. Res. Commun. 81: 1268-1277. PMID 666819.
↑ Beg, Z.H., Stonik, J.A. and Brewer, H.B., Jr. (1985). „Phosphorylation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and modulation of its enzymic activity by calcium-activated and phospholipid-dependent protein kinase”. J. Biol. Chem. 260: 1682-1687. PMID 3155737.
↑ Clarke, P.R. and Hardie, D.G. (1990). „Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver”. EMBO J. 9: 2439-2446. PMID 2369897.
↑ Sato, R., Goldstein, J.L. and Brown, M.S. (1993). „Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion”. Proc. Natl. Acad. Sci. USA 90: 9261-9265. PMID 8415689.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Dephospho-(reductase+kinase)+kinase

[1] Beg, Z.H., Stonik, J.A. and Brewer, H.B., Jr. (1979). „Characterization and regulation of reductase kinase, a protein kinase that modulates the enzymic activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase”. Proc. Natl. Acad. Sci. USA 76: 4375-4379. PMID 291971.

[2] Ingebritsen, T.S., Lee, H.-S., Parker, R.A. and Gibson, D.M. (1978). „Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation”. Biochem. Biophys. Res. Commun. 81: 1268-1277. PMID 666819.

[3] Beg, Z.H., Stonik, J.A. and Brewer, H.B., Jr. (1985). „Phosphorylation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and modulation of its enzymic activity by calcium-activated and phospholipid-dependent protein kinase”. J. Biol. Chem. 260: 1682-1687. PMID 3155737.

[4] Clarke, P.R. and Hardie, D.G. (1990). „Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver”. EMBO J. 9: 2439-2446. PMID 2369897.

[5] Sato, R., Goldstein, J.L. and Brown, M.S. (1993). „Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion”. Proc. Natl. Acad. Sci. USA 90: 9261-9265. PMID 8415689.

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