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Butirat-KoA ligaza
Identifikatori
EC broj	6.2.1.2
CAS broj	9080-51-7
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Butirat-KoA ligaza (EC 6.2.1.2, butiril-KoA sintetaza, masno kiselinska tiokinaza (lanca srednje dužine), acil-altivirajući enzim, masno kiselinska elongaza, masno kiselinski aktivirajući enzim, masna acil koenzim A sintetaza, sintetaza acil-KoA srednje dužine lanca, butiril-koenzim A sintetaza, L-(+)-3-hidroksibutiril KoA ligaza, sintetaza acil-KoA kratkog lanca) je enzim sa sistematskim imenom butanoat:KoA ligaza (formira AMP).^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + karboksilat + KoA

\rightleftharpoons

AMP + difosfat + acil-KoA

Ovaj enzim deluje na kiseline sa C4 do C11 dugim lancom.

Reference

↑ Mahler, H.R., Wakil, S.J. and Bock, R.M. (1953). „Studies on fatty acid oxidation. I. Enzymatic activation of fatty acids”. J. Biol. Chem. 204: 453-468. PMID 13084616.
↑ Massaro, E.J. and Lennarz, W.J. (1965). „The partial purification and characterization of a bacterial fatty acyl coenzyme A synthetase”. Biochemistry 4: 85-90. PMID 14285249.
↑ Websterlt, J.R., Gerowin, L.D. and Rakita, L. (1965). „Purification and characteristics of a butyryl coenzyme A synthetase from bovine heart mitochondria”. J. Biol. Chem. 240: 29-33. PMID 14253428.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Butyrate---CoA+ligase

[1] Mahler, H.R., Wakil, S.J. and Bock, R.M. (1953). „Studies on fatty acid oxidation. I. Enzymatic activation of fatty acids”. J. Biol. Chem. 204: 453-468. PMID 13084616.

[2] Massaro, E.J. and Lennarz, W.J. (1965). „The partial purification and characterization of a bacterial fatty acyl coenzyme A synthetase”. Biochemistry 4: 85-90. PMID 14285249.

[3] Websterlt, J.R., Gerowin, L.D. and Rakita, L. (1965). „Purification and characteristics of a butyryl coenzyme A synthetase from bovine heart mitochondria”. J. Biol. Chem. 240: 29-33. PMID 14253428.

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