Bifenil-2,3-diol 1,2-dioksigenaza

Bifenil-2,3-diol 1,2-dioksigenaza
Identifikatori
EC broj	1.13.11.39
CAS broj	103679-58-9
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Bifenil-2,3-diol 1,2-dioksigenaza (EC 1.13.11.39, 2,3-dihidroksibifenilna dioksigenaza, bifenil-2,3-diolna dioksigenaza, bphC (gen)) je enzim sa sistematskim imenom bifenil-2,3-diol:kiseonik 1,2-oksidoreduktaza (deciklizacija).^{[1][2][3][4][5]} Ovaj enzim katalizuje sledeću hemijsku reakciju

bifenil-2,3-diol + O₂ ${\displaystyle \rightleftharpoons }$ 2-hidroksi-6-okso-6-fenilheksa-2,4-dienoat

Ovaj enzim sadrži Fe²⁺ ili Mn²⁺. On učestvuje u degradaciji bifenila i PCB (poli hlorinatih bifenila)

Reference

1. Eltis, L.D., Hofmann, B., Hecht, H.J., Lunsdorf, H. and Timmis, K.N. (1993). „Purification and crystallization of 2,3-dihydroxybiphenyl 1,2-dioxygenase”. J. Biol. Chem. 268: 2727-2732. PMID 8428946. 
2. Uragami, Y., Senda, T., Sugimoto, K., Sato, N., Nagarajan, V., Masai, E., Fukuda, M. and Mitsu, Y. (2001). „Crystal structures of substrate free and complex forms of reactivated BphC, an extradiol type ring-cleavage dioxygenase”. J. Inorg. Biochem. 83: 269-279. PMID 11293547. 
3. Hatta, T., Mukerjee-Dhar, G., Damborsky, J., Kiyohara, H. and Kimbara, K. (2003). „Characterization of a novel thermostable Mn(II)-dependent 2,3-dihydroxybiphenyl 1,2-dioxygenase from a polychlorinated biphenyl- and naphthalene-degrading Bacillus sp. JF8”. J. Biol. Chem. 278: 21483-21492. PMID 12672826. 
4. Wesche, J., Hammer, E., Becher, D., Burchhardt, G. and Schauer, F. (2005). „The bphC gene-encoded 2,3-dihydroxybiphenyl-1,2-dioxygenase is involved in complete degradation of dibenzofuran by the biphenyl-degrading bacterium Ralstonia sp. SBUG 290”. J. Appl. Microbiol. 98: 635-645. PMID 15715866. 
5. Iwata, K., Nojiri, H., Shimizu, K., Yoshida, T., Habe, H. and Omori, T. (2003). „Expression, purification, and characterization of 2′-aminobiphenyl-2,3-diol 1,2-dioxygenase from carbazole-degrader Pseudomonas resinovorans strain CA10”. Biosci. Biotechnol. Biochem. 67: 300-307. PMID 12728990. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Biphenyl-2,3-diol+1,2-dioxygenase