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Beta-amirin 11-oksidaza
Identifikatori
EC broj	1.14.13.134
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Beta-amirin 11-oksidaza (EC 1.14.13.134, ''CYP88D6'') je enzim sa sistematskim imenom beta-amirin,NADPH:kiseonik oksidoreduktaza (hidroksilacija).^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

beta-amirin + 2 O₂ + 2 NADPH + 2 H⁺

\rightleftharpoons

11-okso-beta-amirin + 3H₂O + 2 NADP⁺ (sveukupna reakcija)

(1a) beta-amirin + O₂ + NADPH + H⁺

\rightleftharpoons

11alfa-hidroksi-beta-amirin + H₂O + NADP⁺

(1b) 11alfa-hidroksi-beta-amirin + O₂ + NADPH + H⁺

\rightleftharpoons

11-okso-beta-amirin + 2H₂O + NADP⁺

Za rad ovog enzim je neophodan citohrom P450. Ovaj enzim učestvuje u biosintezi glicirhizina.

Reference

↑ Seki, H., Ohyama, K., Sawai, S., Mizutani, M., Ohnishi, T., Sudo, H., Akashi, T., Aoki, T., Saito, K. and Muranaka, T. (2008). „Licorice β-amyrin 11-oxidase, a cytochrome P₄₅₀ with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin”. Proc. Natl. Acad. Sci. USA 105: 14204-14209. PMID 18779566.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Beta-amyrin+11-oxidase

[1] Seki, H., Ohyama, K., Sawai, S., Mizutani, M., Ohnishi, T., Sudo, H., Akashi, T., Aoki, T., Saito, K. and Muranaka, T. (2008). „Licorice β-amyrin 11-oxidase, a cytochrome P₄₅₀ with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin”. Proc. Natl. Acad. Sci. USA 105: 14204-14209. PMID 18779566.

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