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Aktivator faktora V zmijskog venuma
Identifikatori
EC broj	3.4.21.95
CAS broj	123757-15-3, 123757-16-4, 123757-17-5, 123757-18-6&title= 471269-12-2, 123757-15-3, 123757-16-4, 123757-17-5, 123757-18-6
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Aktivator faktora V zmijskog venuma (EC 3.4.21.95, Snake venom factor V activator) je enzim.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

Potpuna aktivacija ljudskog faktora zgrušavanja V jednim presecanjem Trp-Tyr-Leu-Arg1545-Ser-Asn-Asn--Gly veze. Goveđi, ali ne i zečji, faktor V se preseca, i ne dolazi do reakcije na drugim proteinima sistema zgrušavanja. Esterazna aktivnost je primećena na Bz-Arg-OEt i Tos-Arg-OMe, i amidazna na Phe-pipekolil-Arg-NHPhNO₂

Ovaj enzim je izolovan iz venuma Vipera russelli.

Reference

↑ Kisiel, W. and Canfield, W. (1981). „M. Snake venom proteases that activate blood-coagulation factor V”. Methods Enzymol. 80: 275-285. PMID 7043192.
↑ Tokunaga, F., Nagasawa, K., Tamura, S., Miyata, T., Iwanaga, S. and Kisiel, W. (1988). „The factor V-activating enzyme (RVV-V) from Russell's viper venom. Identification of isoproteins RVV-Vα, -Vβ and -Vγ and their complete amino acid sequences”. J. Biol. Chem. 263: 17417-17481. PMID 3053712.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Snake+venom+factor+V+activator

[1] Kisiel, W. and Canfield, W. (1981). „M. Snake venom proteases that activate blood-coagulation factor V”. Methods Enzymol. 80: 275-285. PMID 7043192.

[2] Tokunaga, F., Nagasawa, K., Tamura, S., Miyata, T., Iwanaga, S. and Kisiel, W. (1988). „The factor V-activating enzyme (RVV-V) from Russell's viper venom. Identification of isoproteins RVV-Vα, -Vβ and -Vγ and their complete amino acid sequences”. J. Biol. Chem. 263: 17417-17481. PMID 3053712.

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