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Akrocilindropepsin
Identifikatori
EC broj	3.4.23.28
CAS broj	37288-84-9
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Akrocilindropepsin (EC 3.4.23.28, Acrocylindrium proteinaza, Acrocylindrium kiselinska proteinaza) je enzim.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Postoji preferencija za hidrofobne ostatake u P1 i P1'. Dejstvo na B lanac insulina je generalno slično sa pepsinom A, ali dolazi i do razlaganja Leu⁶-Cys(SO₃H), Glu²¹-Arg i Asn³-Gln, mada ne Gln⁴-His

Ovaj enzim je prisutan u glivi Acrocylindrium sp.

Reference

↑ Uchino, F., Kurono, Y. and Doi, S. (1967). „Purification and some properties of crystalline acid protease from Acrocylindrium sp”. Agric. Biol. Chem. 31: 428-434.
↑ Ichihara, S. and Uchino, F. (1975). „The specificity of acid proteinase from Acrocylindrium”. Agric. Biol. Chem. 39: 423-428.
↑ Takahashi, K. and Chang, W.-J. (1976). „The structure and function of acid proteases. V. Comparative studies on the specific inhibition of acid proteases by diazoacetyl-DL-norleucine methyl ester, 1,2-epoxy-3-(p-nitrophenoxy)propane and pepstatin”. J. Biochem. (Tokyo) 80: 497-506. PMID 10290.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Acrocylindropepsin

[1] Uchino, F., Kurono, Y. and Doi, S. (1967). „Purification and some properties of crystalline acid protease from Acrocylindrium sp”. Agric. Biol. Chem. 31: 428-434.

[2] Ichihara, S. and Uchino, F. (1975). „The specificity of acid proteinase from Acrocylindrium”. Agric. Biol. Chem. 39: 423-428.

[3] Takahashi, K. and Chang, W.-J. (1976). „The structure and function of acid proteases. V. Comparative studies on the specific inhibition of acid proteases by diazoacetyl-DL-norleucine methyl ester, 1,2-epoxy-3-(p-nitrophenoxy)propane and pepstatin”. J. Biochem. (Tokyo) 80: 497-506. PMID 10290.

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