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Acil-homoserin-laktonska acilaza
Identifikatori
EC broj	3.5.1.97
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Acil-homoserin-laktonska acilaza (EC 3.5.1.97, acil-homoserin laktonska acilaza, AHL-acilaza, AiiD, N-acil-homoserin laktonska acilaza, PA2385 protein, PvdQ, QuiP) je enzim sa sistematskim imenom N-acil-L-homoserin-lakton amidohidrolaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

N-acil-L-homoserin lakton + H₂O

\rightleftharpoons

L-homoserin lakton + karboksilat

Acil-homoserinske laktone (AHL) formiraju brojne bakterijske vrste.

Reference

↑ Sio, C.F., Otten, L.G., Cool, R.H., Diggle, S.P., Braun, P.G., Bos, R., Daykin, M., Cámara, M., Williams, P. and Quax, W.J. (2006). „Quorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1”. Infect. Immun. 74: 1673-1682. PMID 16495538.
↑ Lin, Y.H., Xu, J.L., Hu, J., Wang, L.H., Ong, S.L., Leadbetter, J.R. and Zhang, L.H. (2003). „Acyl-homoserine lactone acylase from Ralstonia strain XJ12B represents a novel and potent class of quorum-quenching enzymes”. Mol. Microbiol. 47: 849-860. PMID 12535081.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Acyl-homoserine-lactone+acylase

[1] Sio, C.F., Otten, L.G., Cool, R.H., Diggle, S.P., Braun, P.G., Bos, R., Daykin, M., Cámara, M., Williams, P. and Quax, W.J. (2006). „Quorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1”. Infect. Immun. 74: 1673-1682. PMID 16495538.

[2] Lin, Y.H., Xu, J.L., Hu, J., Wang, L.H., Ong, S.L., Leadbetter, J.R. and Zhang, L.H. (2003). „Acyl-homoserine lactone acylase from Ralstonia strain XJ12B represents a novel and potent class of quorum-quenching enzymes”. Mol. Microbiol. 47: 849-860. PMID 12535081.

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