Acetoin dehidrogenaza

Acetoin dehidrogenaza
Identifikatori
EC broj	2.3.1.190
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Acetoin dehidrogenaza (EC 2.3.1.190, acetoin dehidrogenazni kompleks, acetoin dehidrogenazni enzimski sistem, AoDH ES) je enzim sa sistematskim imenom acetil-KoA:acetoin O-acetiltransferaza.^{[1][2][3][4][5]} Ovaj enzim katalizuje sledeću hemijsku reakciju

acetoin + KoA + NAD⁺ ${\displaystyle \rightleftharpoons }$ acetaldehid + acetil-KoA + NADH + H⁺

Za rad ovog enzima je neophodan tiamin difosfat.

Reference

1. Priefert, H., Hein, S., Kruger, N., Zeh, K., Schmidt, B. and Steinbuchel, A. (1991). „Identification and molecular characterization of the Alcaligenes eutrophus H16 aco operon genes involved in acetoin catabolism”. J. Bacteriol. 173: 4056-4071. PMID 2061286. 
2. Oppermann, F.B. and Steinbuchel, A. (1994). „Identification and molecular characterization of the aco genes encoding the Pelobacter carbinolicus acetoin dehydrogenase enzyme system”. J. Bacteriol. 176: 469-485. PMID 8110297. 
3. Kruger, N., Oppermann, F.B., Lorenzl, H. and Steinbuchel, A. (1994). „Biochemical and molecular characterization of the Clostridium magnum acetoin dehydrogenase enzyme system”. J. Bacteriol. 176: 3614-3630. PMID 8206840. 
4. Huang, M., Oppermann, F.B. and Steinbuchel, A. (1994). „Molecular characterization of the Pseudomonas putida 2,3-butanediol catabolic pathway”. FEMS Microbiol. Lett. 124: 141-150. PMID 7813883. 
5. Huang, M., Oppermann-Sanio, F.B. and Steinbuchel, A. (1999). „Biochemical and molecular characterization of the Bacillus subtilis acetoin catabolic pathway”. J. Bacteriol. 181: 3837-3841. PMID 10368162. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Acetoin+dehydrogenase