Acetilgalaktozaminil-O-glikozil-glikoprotein b-1,3-N-acetilglukozaminiltransferaza

Acetilgalaktozaminil-O-glikozil-glikoprotein b-1,3-N-acetilglukozaminiltransferaza
Identifikatori
EC broj	2.4.1.147
CAS broj	87927-96-6
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Acetilgalaktozaminil-O-glikozil-glikoprotein b-1,3-N-acetilglukozaminiltransferaza (EC 2.4.1.147, O-glikozil-oligosaharid-glikoprotein N-acetilglukozaminiltransferaza III, uridin difosfoacetilglukozamin-mucin beta(1->3)-acetilglukozaminiltransferaza, mucinska osnova 3 beta3-GlcNAc-transferaza, UDP-N-acetil-D-glukozamin:O-glikozil-glikoprotein (N-acetil-D-glukozamin na N-acetil-D-galaktozaminil-R) beta-1,3-N-acetil-D-glukozaminiltransferaza) je enzim sa sistematskim imenom UDP-N-acetil-D-glukozamin:N-acetil-beta-D-galaktozaminil-R 3-beta-N-acetil-D-glukozaminiltransferaza.^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-N-acetil-D-glukozamin + N-acetil-beta-D-galaktozaminil-R ${\displaystyle \rightleftharpoons }$ UDP + N-acetil-beta-D-glukozaminil-(1->3)-N-acetil-beta-D-galaktozaminil-R

Povezano

• EC 2.4.1.102 (beta-1,3-galaktozil-O-glikozil-glikoprotein beta-1,6-N-acetilglukozaminiltransferaza)
• EC 2.4.1.146 (beta-1,3-galaktozil-O-glikozil-glikoprotein beta-1,3-N-acetilglukozaminiltransferaza)
• EC 2.4.1.148 (acetilgalaktozaminil-O-glikozil-glikoprotein beta-1,6-N-acetilglukozaminiltransferaza)

Reference

1. Brockhausen, I., Rachaman, E.S., Matta, K.L. and Schachter, H. (1983). „The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis”. Carbohydr. Res. 120: 3-16. PMID 6226356. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH Acetylgalactosaminyl-O-glycosyl-glycoprotein+beta-1,3-N-acetylglucosaminyltransferase