ADP-ribozilargininska hidrolaza

ADP-ribozilargininska hidrolaza
Identifikatori
EC broj	3.2.2.19
CAS broj	98668-52-1
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

ADP-ribozilargininska hidrolaza (EC 3.2.2.19, enzim razlaganja ADP-riboza-L-arginina, Nomega-(ADP-D-ribozil)-L-arginin ADP-ribozilhidrolaza, protein-omega-N-(ADP-D-ribozil)-L-arginin ADP-ribozilhidrolaza) je enzim sa sistematskim imenom protein-Nomega-(ADP-D-ribozil)-L-arginin ADP-ribozilhidrolaza.^{[1][2][3][4][5]} Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) protein-N^omega-(ADP-D-ribozil)-L-arginin + H₂O ${\displaystyle \rightleftharpoons }$ ADP-riboza + protein-L-arginin

(2) N^omega-(ADP-D-ribozil)-L-arginin + H₂O ${\displaystyle \rightleftharpoons }$ ADP-riboza + L-arginin

Ovaj enzim uklanja ADP-ribozu sa argininskih ostataka u ADP-ribozilisanim proteinima.

Reference

1. Moss, J., Jacobson, M.K. and Stanley, S.J. (1985). „Reversibility of arginine-specific mono(ADP-ribosyl)ation: identification in erythrocytes of an ADP-ribose-L-arginine cleavage enzyme”. Proc. Natl. Acad. Sci. USA 82: 5603-5607. PMID 2994036. 
2. Moss, J., Stanley, S.J., Nightingale, M.S., Murtagh, J.J., Jr., Monaco, L., Mishima, K., Chen, H.C., Williamson, K.C. and Tsai, S.C. (1992). „Molecular and immunological characterization of ADP-ribosylarginine hydrolases”. J. Biol. Chem. 267: 10481-10488. PMID 1375222. 
3. Konczalik, P. and Moss, J. (1999). „Identification of critical, conserved vicinal aspartate residues in mammalian and bacterial ADP-ribosylarginine hydrolases”. J. Biol. Chem. 274: 16736-16740. PMID 10358013. 
4. Takada, T., Iida, K. and Moss, J. (1993). „Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase”. J. Biol. Chem. 268: 17837-17843. PMID 8349667. 
5. Ohno, T., Tsuchiya, M., Osago, H., Hara, N., Jidoi, J. and Shimoyama, M. (1995). „Detection of arginine-ADP-ribosylated protein using recombinant ADP-ribosylarginine hydrolase”. Anal. Biochem. 10: 115-122. PMID 8678289. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH (protein+ADP-ribosylarginine)+hydrolase