8-Amino-7-oksononanoat sintaza

8-amino-7-oksononanoat sintaza
Identifikatori
EC broj	2.3.1.47
CAS broj	9075-61-0
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

8-amino-7-oksononanoat sintaza (EC 2.3.1.47, 7-keto-8-aminopelargonsko kiselinska sintetaza, 7-keto-8-aminopelargonska sintetaza, 8-amino-7-oksopelargonatna sintaza) je enzim sa sistematskim imenom 6-karboksiheksanoil-KoA:L-alanin C-karboksiheksanoiltransferaza (dekarboksilacija).^[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

6-karboksiheksanoil-KoA + L-alanin ${\displaystyle \rightleftharpoons }$ 8-amino-7-oksononanoat + KoA + CO₂

Ovaj enzim je piridoksal-fosfatni protein.

Reference

1. Eisenberg, M.A. and Star, C. (1968). „Synthesis of 7-oxo-8-aminopelargonic acid, a biotin vitamer, in cell-free extracts of Escherichia coli biotin auxotrophs”. J. Bacteriol. 96: 1291-1297. PMID 4879561. 
2. Alexeev, D., Alexeeva, M., Baxter, R.L., Campopiano, D.J., Webster, S.P. and Sawyer, L. (1998). „The crystal structure of 8-amino-7-oxononanoate synthase: a bacterial PLP-dependent, acyl-CoA-condensing enzyme”. J. Mol. Biol. 284: 401-419. PMID 9813126. 
3. Ploux, O., Breyne, O., Carillon, S. and Marquet, A. (1999). „Slow-binding and competitive inhibition of 8-amino-7-oxopelargonate synthase, a pyridoxal-5′-phosphate-dependent enzyme involved in biotin biosynthesis, by substrate and intermediate analogs. Kinetic and binding studies”. Eur. J. Biochem. 259: 63-70. PMID 9914476. 
4. Webster, S.P. (2000). „, Alexeev. D., Campopiano, D.J., Watt, R.M., Alexeeva, M., Sawyer, L. and Baxter, R. Mechanism of 8-amino-7-oxononanoate synthase: spectroscopic, kinetic, and crystallographic studies”. Biochemistry 39: 516-528. PMID 10642176. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Spoljašnje veze

• MeSH 8-amino-7-oxononanoate+synthase