6-hidroksipseudooksinikotin dehidrogenaza

6-hidroksipseudooksinikotin dehidrogenaza
Identifikatori
EC broj	1.5.99.14
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

6-hidroksipseudooksinikotin dehidrogenaza (EC 1.5.99.14, 6-hidroksipseudooksinikotinska dehidrogenaza) je enzim sa sistematskim imenom 1-(6-hidroksipiridin-3-il)-4-(metilamino)butan-1-on:akceptor 6-oksidoreduktaza (hidroksilacija).^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju:

1-(6-hidroksipiridin-3-il)-4-(metilamino)butan-1-on + akceptor + H₂O ${\displaystyle \rightleftharpoons }$ 1-(2,6-dihidroksipiridin-3-il)-4-(metilamino)butan-1-on + redukovani akceptor

Ovaj enzim sadrži citidilil molibdenijum kofaktor.

Reference

1. Freudenberg, W., Konig, K. and Andreesen, J. R. (1988). „Nicotine dehydrogenase from Arthrobacter oxidans: A molybdenum-containing hydroxylase”. FEMS Microbiology Letters 52: 13-18. 
2. Grether-Beck, S., Igloi, G.L., Pust, S., Schilz, E., Decker, K. and Brandsch, R. (1994). „Structural analysis and molybdenum-dependent expression of the pAO1-encoded nicotine dehydrogenase genes of Arthrobacter nicotinovorans”. Mol. Microbiol. 13: 929-936. PMID 7815950. 
3. Sachelaru, P., Schiltz, E. and Brandsch, R. (2006). „A functional mobA gene for molybdopterin cytosine dinucleotide cofactor biosynthesis is required for activity and holoenzyme assembly of the heterotrimeric nicotine dehydrogenases of Arthrobacter nicotinovorans”. Appl. Environ. Microbiol. 72: 5126-5131. PMID 16820521. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH 6-hydroxypseudooxynicotine+dehydrogenase