4-hidroksibenzoil-KoA reduktaza

4-hidroksibenzoil-KoA reduktaza
Identifikatori
EC broj	1.3.7.9
CAS broj	133758-58-4
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

4-hidroksibenzoil-KoA reduktaza (EC 1.3.7.9, 4-hidroksibenzoil-KoA reduktaza (dehidroksilating), 4-hidroksibenzoil-KoA:(akceptor) oksidoreduktaza) je enzim sa sistematskim imenom benzoil-KoA:akceptor oksidoreduktaza.^{[1][2][3][4][5]} Ovaj enzim katalizuje sledeću hemijsku reakciju

benzoil-KoA + oksidovani feredoksin + H₂O ${\displaystyle \rightleftharpoons }$ 4-hidroksibenzoil-KoA + redukovani feredoksin

Ovaj molibden-flavin-gvožđe-sumpor protein učestvuje u anaerobnom putu fenolnog metabolizma kod bakterija. Feredoksin sa dva [4Fe-4S] klustera funkcioniše kao prirodni donor elektrona.

Reference

1. Glockler, R., Tschech, A. and Fuchs, G. (1989). „Reductive dehydroxylation of 4-hydroxybenzoyl-CoA to benzoyl-CoA in a denitrifying, phenol-degrading Pseudomonas species”. FEBS Lett. 251: 237-240. PMID 2753161. 
2. Heider, J., Boll, M., Breese, K., Breinig, S., Ebenau-Jehle, C., Feil, U., Gad'on, N., Laempe, D., Leuthner, B., Mohamed, M.E.S., Schneider, S., Burchhardt, G. and Fuchs, G. (1998). „Differential induction of enzymes involved in anaerobic metabolism of aromatic compounds in the denitrifying bacterium Thauera aromatica”. Arch. Microbiol. 170: 120-131. PMID 9683649. 
3. Breese, K. and Fuchs, G. (1998). „4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from the denitrifying bacterium Thauera aromatica - prosthetic groups, electron donor, and genes of a member of the molybdenum-flavin-iron-sulfur proteins”. Eur. J. Biochem. 251: 916-923. PMID 9490068. 
4. Brackmann, R. and Fuchs, G. (1993). „Enzymes of anaerobic metabolism of phenolic compounds. 4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from a denitrifying Pseudomonas species”. Eur. J. Biochem. 213: 563-571. PMID 8477729. 
5. Heider, J. and Fuchs, G. (1997). „Anaerobic metabolism of aromatic compounds”. Eur. J. Biochem. 243: 577-596. PMID 9057820. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH 4-hydroxybenzoyl-CoA+reductase