4-Kumarat-KoA ligaza

4-kumarat-KoA ligaza
Identifikatori
EC broj	6.2.1.12
CAS broj	37332-51-7
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

4-kumarat-KoA ligaza (EC 6.2.1.12, 4-kumaroil-KoA sintetaza, p-kumaroil KoA ligaza, p-kumaril koenzim A sintetaza, p-kumaril-KoA sintetaza, p-kumaril-KoA ligaza, feruloil KoA ligaza, hidroksicinamoil KoA sintetaza, 4-kumarat:koenzim A ligaza, kafeolil koenzim A sintetaza, p-hidroksicinamoil koenzim A sintetaza, feruloil koenzim A sintetaza, sinapoil koenzim A sintetaza, 4-kumaril-KoA sintetaza, hidroksicinamat:KoA ligaza, p-kumaril-KoA ligaza, p-hidroksicinaminska kiselina:KoA ligaza, 4CL) je enzim sa sistematskim imenom 4-kumarat:KoA ligaza (formira AMP).^[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + 4-kumarat + KoA ${\displaystyle \rightleftharpoons }$ AMP + difosfat + 4-kumaroil-KoA

Reference

1. Gross, G.G. and Zenk, M.H. (1974). „Isolation and properties of hydroxycinnamate: CoA ligase from lignifying tissue of Forsythia”. Eur. J. Biochem. 42: 453-459. PMID 4364250. 
2. Lindl, T., Kreuzaler, F. and Hahlbrock, F. (1973). „Synthesis of p-coumaroyl coenzyme A with a partially purified p-coumarate:CoA ligase from cell suspension cultures of soybean (Glycine max)”. Biochim. Biophys. Acta 302: 457-464. PMID 4699252. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH 4-coumarate---CoA+ligase