4-Hidroksifenilacetaldehid oksim monooksigenaza

4-Hidroksifenilacetaldehid oksim monooksigenaza
Identifikatori
EC broj	1.14.13.68
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

4-Hidroksifenilacetaldehid oksim monooksigenaza (EC 1.14.13.68, 4-hidroksibenzenacetaldehid oksimska monooksigenaza, citohrom P450II-zavisna monooksigenaza, NADPH-citohrom P450 reduktaza (CYP71E1), CYP71E1, 4-hidroksifenilacetaldehid oksim,NADPH:kiseonik oksidoreduktaza) je enzim sa sistematskim imenom (Z)-4-hidroksifenilacetaldehid oksim,NADPH:kiseonik oksidoreduktaza.^[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

(Z)-4-hidroksifenilacetaldehid oksim + NADPH + H⁺ + O₂ ${\displaystyle \rightleftharpoons }$ (S)-4-hidroksimandelonitril + NADP⁺ + 2H₂O

Ovaj enzim učestvuju u biosintezi cijanogenig glukozida dhurina.

Reference

1. MacFarlane, I.J., Lees, E.M. and Conn, E.E. (1975). „The in vitro biosynthesis of dhurrin, the cyanogenic glycoside of Sorghum bicolor”. J. Biol. Chem. 250: 4708-4713. PMID 237909. 
2. Shimada, M. and Conn, E.E. (1977). „The enzymatic conversion of p-hydroxyphenylacetaldoxime to p-hydroxymandelonitrile”. Arch. Biochem. Biophys. 180: 199-207. PMID 193443. 
3. Busk, P.K. and Møller, B.L. (2002). „Dhurrin synthesis in sorghum is regulated at the transcriptional level and induced by nitrogen fertilization in older plants”. Plant Physiol. 129: 1222-1231. PMID 12114576. 
4. Kristensen, C., Morant, M., Olsen, C.E., Ekstrøm, C.T., Galbraith, D.W., Møller, B.L. and Bak, S. (2005). „Metabolic engineering of dhurrin in transgenic Arabidopsis plants with marginal inadvertent effects on the metabolome and transcriptome”. Proc. Natl. Acad. Sci. USA 102: 1779-1784. PMID 15665094. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH 4-hydroxyphenylacetaldehyde+oxime+monooxygenase