2-Metil-enoil-razranatog-lanca-KoA reduktaza

2-metil-enoil-razranatog-lanca-KoA reduktaza
Identifikatori
EC broj	1.3.1.52
CAS broj	122320-06-3
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

2-Metil-enoil-razranatog-lanca-KoA reduktaza (EC 1.3.1.52, reduktaza 2-metil-enoila-razranatog-lanca-KoA) je enzim sa sistematskim imenom 2-metil-razgranati-lanac-acil-KoA:NAD⁺ 2-oksidoreduktaza.^[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju

2-metilbutanoil-KoA + NAD⁺ ${\displaystyle \rightleftharpoons }$ 2-metilkrotonoil-KoA + NADH + H⁺

Ovaj enzim je flavoprotein (FAD) iz Ascaris suum. Reakcija se odvija samo u prisustvu drugih flavoproteina (elektron-transfer flavoproteina).

Reference

1. Komuniecki, R., Fekete, S. and Thissen-Parra, J. (1985). „Purification and characterization of the 2-methyl branched-chain acyl-CoA dehydrogenase, an enzyme involved in NADH-dependent enoyl-CoA reduction in anaerobic mitochondria of the nematode, Ascaris suum”. J. Biol. Chem. 260: 4770-4777. PMID 3988734. 
2. Komuniecki, R., McCrury, J., Thissen, J. and Rubin, N. (1989). „Electron-transfer flavoprotein from anaerobic Ascaris suum mitochondria and its role in NADH-dependent 2-methyl branched-chain enoyl-CoA reduction”. Biochim. Biophys. Acta 975: 127-131. PMID 2736251. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH 2-methyl-branched-chain-enoyl-CoA+reductase