(Heparan sulfat)-glukozamin N-sulfotransferaza

(heparan sulfat)-glukozamin N-sulfotransferaza
Identifikatori
EC broj	2.8.2.8
CAS broj	9026-75-9
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

(heparan sulfat)-glukozamin N-sulfotransferaza (EC 2.8.2.8, heparinska N-sulfotransferaza, 3'-fosfoadenililsulfat:N-desulfoheparin sulfotransferaza, PAPS:N-desulfoheparin sulfotransferaza, PAPS:DSH sulfotransferaza, N-HSST, N-heparan sulfatna sulfotransferaza, heparan sulfat N-deacetilase/N-sulfotransferaza, heparan sulfatna 2-N-sulfotransferaza, heparan sulfatna N-sulfotransferaza, heparan sulfatna sulfotransferaza, N-desulfoheparinska sulfotransferaza, desulfoheparinska sulfotransferaza, 3'-fosfoadenilil-sulfat:N-desulfoheparin N-sulfotransferaza, heparitinska sulfotransferaza, 3'-fosfoadenilil-sulfat:heparitin N-sulfotransferaza) je enzim sa sistematskim imenom 3'-fosfoadenilil-sulfat:(heparan sulfat)-glukozamin N-sulfotransferaza.^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

3'-fosfoadenilil sulfat + [heparan sulfat]-glukozamin ${\displaystyle \rightleftharpoons }$ adenozin 3',5'-bisfosfat + [heparan sulfat]-N-sulfoglukozamin

Ovaj enzim takođe katalizuje sulfaciju hondroitin 4-sulfata i dermatan sulfata.

Reference

1. Suzuki, S., Trenn, R.H. and Strominger, J.L. (1961). „Separation of specific mucopolysaccharide sulfotransferases”. Biochim. Biophys. Acta 50: 169-174. 
2. Eisenman, R.A., Balasubramanian, A.S. and Marx, W. (1967). „3′-Phosphoadenylylsulfate:N-desulfoheparin sulfotransferase associated with a postmicrosomal particulate mastocytoma fraction”. Arch. Biochem. Biophys. 119: 387-397. PMID 4964017. 
3. Johnson, A.H. and Baker, J.R. (1973). „The enzymatic sulphation of heparan sulphate by hen's uterus”. Biochim. Biophys. Acta 320: 341-351. PMID 4270798. 

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

• MeSH (heparan+sulfate)-glucosamine+N-sulfotransferase