Richard Axel

Richard Axel

Nascimento 2 de julho de 1946 (78 anos)
Nova Iorque
Alma mater Stuyvesant High School, Universidade Columbia, Escola de Medicina Johns Hopkins
Prêmios Prêmio Eli Lilly de Química Biológica (1983), Nobel de Fisiologia ou Medicina (2004), Medalha Dupla Hélice (2007)
Instituições Universidade Columbia
Campo(s) medicina

Richard Axel (Nova Iorque, 2 de julho de 1946) é um médico estadunidense.

Foi agraciado, juntamente com Linda Buck, com o Nobel de Fisiologia ou Medicina de 2004, por trabalhos sobre os receptores de odores e a organização do sistema olfativo.

Publicações selecionadas

  • Axel R, Schlom J, Spiegelman S (janeiro de 1972). «Presence in human breast cancer of RNA homologous to mouse mammary tumour virus RNA». Nature. 235 (5332): 32–6. PMID 4332799. doi:10.1038/235032a0 
  • Weinstein IB, Gebert R, Stadler UC, Orenstein JM, Axel R (dezembro de 1972). «Type C virus from cell cultures of chemically induced rat hepatomas». Science. 178 (65): 1098–100. PMID 4343844. doi:10.1126/science.178.4065.1098 
  • McAllister LB, Scheller RH, Kandel ER, Axel R (novembro de 1983). «In situ hybridization to study the origin and fate of identified neurons». Science. 222 (4625): 800–8. PMID 6356362. doi:10.1126/science.6356362 
  • Gay D, Maddon P, Sekaly R,; et al. (1987). «Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigen». Nature. 328 (6131): 626–9. PMID 3112582. doi:10.1038/328626a0 
  • Julius D, MacDermott AB, Axel R, Jessell TM (julho de 1988). «Molecular characterization of a functional cDNA encoding the serotonin 1c receptor». Science. 241 (4865): 558–64. PMID 3399891. doi:10.1126/science.3399891 
  • Deen KC, McDougal JS, Inacker R,; et al. (janeiro de 1988). «A soluble form of CD4 (T4) protein inhibits AIDS virus infection». Nature. 331 (6151): 82–4. PMID 3257544. doi:10.1038/331082a0 
  • Julius D, Livelli TJ, Jessell TM, Axel R (junho de 1989). «Ectopic expression of the serotonin 1c receptor and the triggering of malignant transformation». Science. 244 (4908): 1057–62. PMID 2727693. doi:10.1126/science.2727693 
  • Ryu SE, Kwong PD, Truneh A,; et al. (novembro de 1990). «Crystal structure of an HIV-binding recombinant fragment of human CD4». Nature. 348 (6300): 419–26. PMID 2247146. doi:10.1038/348419a0 
  • Robey EA, Ramsdell F, Kioussis D,; et al. (junho de 1992). «The level of CD8 expression can determine the outcome of thymic selection». Cell. 69 (7): 1089–96. PMID 1617724. doi:10.1016/0092-8674(92)90631-L 
  • Ngai J, Dowling MM, Buck L, Axel R, Chess A (março de 1993). «The family of genes encoding odorant receptors in the channel catfish». Cell. 72 (5): 657–66. PMID 7916654. doi:10.1016/0092-8674(93)90395-7 
  • Ngai J, Chess A, Dowling MM, Necles N, Macagno ER, Axel R (março de 1993). «Coding of olfactory information: topography of odorant receptor expression in the catfish olfactory epithelium». Cell. 72 (5): 667–80. PMID 8453662. doi:10.1016/0092-8674(93)90396-8 
  • Vassar R, Ngai J, Axel R (julho de 1993). «Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium». Cell. 74 (2): 309–18. PMID 8343958. doi:10.1016/0092-8674(93)90422-M 
  • Chess A, Simon I, Cedar H, Axel R (setembro de 1994). «Allelic inactivation regulates olfactory receptor gene expression». Cell. 78 (5): 823–34. PMID 8087849. doi:10.1016/S0092-8674(94)90562-2 
  • Vassar R, Chao SK, Sitcheran R, Nuñez JM, Vosshall LB, Axel R (dezembro de 1994). «Topographic organization of sensory projections to the olfactory bulb». Cell. 79 (6): 981–91. PMID 8001145. doi:10.1016/0092-8674(94)90029-9 
  • Dulac C, Axel R (outubro de 1995). «A novel family of genes encoding putative pheromone receptors in mammals». Cell. 83 (2): 195–206. PMID 7585937. doi:10.1016/0092-8674(95)90161-2 
  • Mombaerts P, Wang F, Dulac C,; et al. (novembro de 1996). «Visualizing an olfactory sensory map». Cell. 87 (4): 675–86. PMID 8929536. doi:10.1016/S0092-8674(00)81387-2 
  • Amrein H, Axel R (fevereiro de 1997). «Genes expressed in neurons of adult male Drosophila». Cell. 88 (4): 459–69. PMID 9038337. doi:10.1016/S0092-8674(00)81886-3 
  • Wang F, Nemes A, Mendelsohn M, Axel R (abril de 1998). «Odorant receptors govern the formation of a precise topographic map». Cell. 93 (1): 47–60. PMID 9546391. doi:10.1016/S0092-8674(00)81145-9 
  • Vosshall LB, Amrein H, Morozov PS, Rzhetsky A, Axel R (março de 1999). «A spatial map of olfactory receptor expression in the Drosophila antenna». Cell. 96 (5): 725–36. PMID 10089887. doi:10.1016/S0092-8674(00)80582-6 
  • Belluscio L, Koentges G, Axel R, Dulac C (abril de 1999). «A map of pheromone receptor activation in the mammalian brain». Cell. 97 (2): 209–20. PMID 10219242. doi:10.1016/S0092-8674(00)80731-X 
  • Vosshall LB, Wong AM, Axel R (julho de 2000). «An olfactory sensory map in the fly brain». Cell. 102 (2): 147–59. PMID 10943836. doi:10.1016/S0092-8674(00)00021-0 
  • Gogos JA, Osborne J, Nemes A, Mendelsohn M, Axel R (novembro de 2000). «Genetic ablation and restoration of the olfactory topographic map». Cell. 103 (4): 609–20. PMID 11106731. doi:10.1016/S0092-8674(00)00164-1 
  • Scott K, Brady R, Cravchik A,; et al. (março de 2001). «A chemosensory gene family encoding candidate gustatory and olfactory receptors in Drosophila». Cell. 104 (5): 661–73. PMID 11257221. doi:10.1016/S0092-8674(01)00263-X 
  • Wong AM, Wang JW, Axel R (abril de 2002). «Spatial representation of the glomerular map in the Drosophila protocerebrum». Cell. 109 (2): 229–41. PMID 12007409. doi:10.1016/S0092-8674(02)00707-9 
  • Wang JW, Wong AM, Flores J, Vosshall LB, Axel R (janeiro de 2003). «Two-photon calcium imaging reveals an odor-evoked map of activity in the fly brain». Cell. 112 (2): 271–82. PMID 12553914. doi:10.1016/S0092-8674(03)00004-7 
  • Cutforth T, Moring L, Mendelsohn M,; et al. (agosto de 2003). «Axonal ephrin-As and odorant receptors: coordinate determination of the olfactory sensory map». Cell. 114 (3): 311–22. PMID 12914696. doi:10.1016/S0092-8674(03)00568-3 
  • Eggan K, Baldwin K, Tackett M,; et al. (março de 2004). «Mice cloned from olfactory sensory neurons». Nature. 428 (6978): 44–9. PMID 14990966. doi:10.1038/nature02375 
  • Barnea G, O'Donnell S, Mancia F,; et al. (junho de 2004). «Odorant receptors on axon termini in the brain». Science. 304 (5676). 1468 páginas. PMID 15178793. doi:10.1126/science.1096146 
  • Shykind BM, Rohani SC, O'Donnell S,; et al. (junho de 2004). «Gene switching and the stability of odorant receptor gene choice». Cell. 117 (6): 801–15. PMID 15186780. doi:10.1016/j.cell.2004.05.015 
  • Lomvardas S, Barnea G, Pisapia DJ, Mendelsohn M, Kirkland J, Axel R (julho de 2006). «Interchromosomal interactions and olfactory receptor choice». Cell. 126 (2): 403–13. PMID 16873069. doi:10.1016/j.cell.2006.06.035 

Ligações externas


Precedido por
Paul Christian Lauterbur e Peter Mansfield
Nobel de Fisiologia ou Medicina
2004
com Linda Buck
Sucedido por
Barry Marshall e John Robin Warren


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