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FAAH
식별자
다른 이름	FAAH, fatty acid amide hydrolase, FAAH-1, PSAB
외부 ID	OMIM: 602935 MGI: 109609 HomoloGene: 68184 GeneCards: FAAH
유전자 위치 (인간)
염색체	1번 염색체
끝	46,413,848 bp
유전자 위치 (쥐)
염색체	4번 염색체 (쥐)
끝	115,875,123 bp
RNA 발현 패턴
	최상위 발현
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; mucosa of transverse colon; ; C1 segment; ; right hemisphere of cerebellum; ; left testis; ; right testis; ; 간오른엽; ; 기댐핵; ; body of pancreas;
	최상위 발현
	dentate gyrus of hippocampal formation granule cell; ; left lobe of liver; ; primary visual cortex; ; CA3 field; ; perirhinal cortex; ; superior frontal gyrus; ; entorhinal cortex; ; right kidney; ; 쓸개; ; hippocampus proper;
	추가 참조 발현 데이터
	n/a
유전자 온톨로지
분자 함수	단백질 결합; 가수분해효소 활성; acylglycerol lipase activity; fatty acid amide hydrolase activity; amidase activity;
세포 성분	세포질; organelle membrane; integral component of membrane; 세포골격; endoplasmic reticulum membrane; 내막계; 세포막;
생물학적 과정	arachidonic acid metabolic process; fatty acid catabolic process; monoacylglycerol catabolic process;
	출처: Amigo / QuickGO
동원체
	2166
	14073
	ENSG00000117480
	ENSMUSG00000034171
	O00519
	O08914
	NM_001441
	NM_010173
	NP_001432
	NP_034303
	위키데이터
인간 보기/편집	쥐 보기/편집

지방산 아마이드 가수분해효소 1(영어: fatty-acid amide hydrolase 1, FAAH)^[5]은 세린 가수분해효소 계열의 일원이다. 지방산 아마이드 가수분해효소 1은 1993년에 N-아실에탄올아민(NAE)인 아난다마이드(AEA)를 분해하는 것으로 처음 밝혀졌다.^[6] 사람의 경우 이 효소는 FAAH 유전자에 의해 암호화되어 있다.^[7]^[8]^[9]

같이 보기

각주

↑ ^가 ^나 ^다 GRCh38: Ensembl release 89: ENSG00000117480 - 앙상블, May 2017
↑ ^가 ^나 ^다 GRCm38: Ensembl release 89: ENSMUSG00000034171 - 앙상블, May 2017
↑ “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.
↑ “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.
↑ “UniProt”. 《www.uniprot.org》. 2023년 7월 18일에 확인함.
↑ Deutsch DG, Chin SA (September 1993). “Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist”. 《Biochemical Pharmacology》 46 (5): 791–796. doi:10.1016/0006-2952(93)90486-G. PMID 8373432.
↑ Cravatt BF, Giang DK, Mayfield SP, Boger DL, Lerner RA, Gilula NB (November 1996). “Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides”. 《Nature》 384 (6604): 83–87. Bibcode:1996Natur.384...83C. doi:10.1038/384083a0. PMID 8900284. S2CID 4288981.
↑ Giang DK, Cravatt BF (March 1997). “Molecular characterization of human and mouse fatty acid amide hydrolases”. 《Proceedings of the National Academy of Sciences of the United States of America》 94 (6): 2238–2242. Bibcode:1997PNAS...94.2238G. doi:10.1073/pnas.94.6.2238. PMC 20071. PMID 9122178.
↑ PDB 1MT5; Bracey MH, Hanson MA, Masuda KR, Stevens RC, Cravatt BF (November 2002). “Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling”. 《Science》 298 (5599): 1793–1796. Bibcode:2002Sci...298.1793B. doi:10.1126/science.1076535. PMID 12459591. S2CID 22656813.

외부 링크

의학주제표목 (MeSH)의 fatty-acid+amide+hydrolase
Proteopedia FAAH entry - interactive structure (JMOL) of inhibitor-bound FAAH
Fatty acid amide hydrolase (FAAH1) Human Protein Atlas

생물학 포털

[refGRCh38Ensembl-1] 가 ^나 ^다 GRCh38: Ensembl release 89: ENSG00000117480 - 앙상블, May 2017

[refGRCm38Ensembl-2] 가 ^나 ^다 GRCm38: Ensembl release 89: ENSMUSG00000034171 - 앙상블, May 2017

[3] “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.

[4] “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.

[UniProt-5] “UniProt”. 《www.uniprot.org》. 2023년 7월 18일에 확인함.

[pmid8373432-6] Deutsch DG, Chin SA (September 1993). “Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist”. 《Biochemical Pharmacology》 46 (5): 791–796. doi:10.1016/0006-2952(93)90486-G. PMID 8373432.

[pmid8900284-7] Cravatt BF, Giang DK, Mayfield SP, Boger DL, Lerner RA, Gilula NB (November 1996). “Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides”. 《Nature》 384 (6604): 83–87. Bibcode:1996Natur.384...83C. doi:10.1038/384083a0. PMID 8900284. S2CID 4288981.

[pmid9122178-8] Giang DK, Cravatt BF (March 1997). “Molecular characterization of human and mouse fatty acid amide hydrolases”. 《Proceedings of the National Academy of Sciences of the United States of America》 94 (6): 2238–2242. Bibcode:1997PNAS...94.2238G. doi:10.1073/pnas.94.6.2238. PMC 20071. PMID 9122178.

[pmid12459591-9] PDB 1MT5; Bracey MH, Hanson MA, Masuda KR, Stevens RC, Cravatt BF (November 2002). “Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling”. 《Science》 298 (5599): 1793–1796. Bibcode:2002Sci...298.1793B. doi:10.1126/science.1076535. PMID 12459591. S2CID 22656813.

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