칼시토닌

CALCA
사용 가능한 구조
PDB	동원체 검색: PDBe RCSB
PDB ID 코드 목록
	2JXZ,%%s1LS7
식별자
다른 이름	CALCA, CT, CGRP-I, CGRP-alpha, KC, PCT, calcitonin related polypeptide alpha, CGRP, CGRP1, CALC1
외부 ID	OMIM: 114130 MGI: 2151253 HomoloGene: 88401 GeneCards: CALCA
유전자 위치 (인간)
염색체	11번 염색체
끝	14,972,351 bp
유전자 위치 (쥐)
염색체	7번 염색체 (쥐)
끝	114,235,592 bp
RNA 발현 패턴
	최상위 발현
	배근 신경절; ; trigeminal ganglion; ; 넙다리네갈래근; ; 가쪽넓은근; ; cerebellar vermis; ; 랑게르한스섬; ; human kidney; ; Epithelium of choroid plexus; ; 앞정강근; ; 간오른엽;
	최상위 발현
	facial motor nucleus; ; 운동 신경세포; ; lumbar spinal ganglion; ; 앞회색질기둥; ; lactiferous gland; ; 기관; ; trigeminal ganglion; ; 배; ; 배; ; vestibular membrane of cochlear duct;
	추가 참조 발현 데이터
	; ; ; ;
	추가 참조 발현 데이터
유전자 온톨로지
분자 함수	hormone activity; calcitonin receptor binding; 단백질 결합; identical protein binding; signaling receptor binding; protein-containing complex binding;
세포 성분	세포질; intracellular anatomical structure; 세포밖공간; 축삭; terminal bouton; soma; neuron projection; 세포핵; 세포 바깥쪽;
생물학적 과정	cellular response to nerve growth factor stimulus; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; negative regulation of smooth muscle contraction; regulation of heart contraction; monocyte chemotaxis; negative regulation of blood pressure; positive regulation of cytosolic calcium ion concentration; cellular response to tumor necrosis factor; 노화; 혈관 확장; cellular calcium ion homeostasis; response to heat; negative regulation of nervous system process; positive regulation of ossification; activation of adenylate cyclase activity; regulation of heart rate; detection of temperature stimulus involved in sensory perception of pain; negative regulation of ossification; response to pain; artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure; 식성; inflammatory response; neuropeptide signaling pathway; negative regulation of transcription, DNA-templated; activation of protein kinase activity; embryo implantation; negative regulation of bone resorption; 신호전달 수용체 활성의 조절; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of cytosolic calcium ion concentration; leukocyte cell-cell adhesion; G protein-coupled receptor internalization; positive regulation of interleukin-1 alpha production; response to yeast; negative regulation of osteoclast differentiation; cell-cell signaling; 항균 체액성 면역 반응; positive regulation of macrophage differentiation; receptor internalization; regulation of blood pressure; 단백질 인산화; vasculature development; defense response to Gram-negative bacterium; endothelial cell proliferation; positive regulation of interleukin-8 production; nervous system process involved in regulation of systemic arterial blood pressure; negative regulation of calcium ion transport into cytosol; 선천면역; endothelial cell migration; 항진균 체액성 면역 반응; defense response to Gram-positive bacterium; 항미생물 펩타이드에 의해 매개되는 항미생물 체액성 면역 반응; amylin receptor signaling pathway; calcitonin gene-related peptide receptor signaling pathway;
	출처: Amigo / QuickGO
동원체
	796
	12310
	ENSG00000110680
	ENSMUSG00000030669
	P06881
	P70160; Q99JA0
	NM_001033952; NM_001033953; NM_001741; NM_001378949; NM_001378950
	NM_001033954; NM_007587; NM_001289444; NM_001305616
	NP_001029125.1
NP_001029126; NP_001276373; NP_001292545; NP_031613; NP_001029126.1;
	NP_001276373.1
	위키데이터
인간 보기/편집	쥐 보기/편집

칼시토닌(Calcitonin)은 인간과 수많은 기타 동물들에서 갑상샘의 난포방세포(이른바 C세포)에 의해 분비되는 32개 아미노산 펩타이드 호르몬이다.^[5] 뼈가 칼슘이온을 방출하는 것을 막아 혈중 칼슘(Ca²⁺) 이온의 농도를 감소시키는 역할을 하며 부갑상선호르몬(PTH, 파라토르몬)의 반대 효과를 보이며 길항작용을 한다.^[6]