알테수네이트/피로나리딘

복합약
Artesunate 항말라리아제
Pyronaridine 항말라리아제
식별 정보
CAS 등록번호 884661-13-6
ATC 코드 P01BF06
PubChem ?
처방 주의사항
임부투여안전성 ?
법적 상태
투여 방법 경구용[1]

알테수네이트/피로나리딘(Artesunate/pyronaridine) 혹은 제품명 피라맥스(Pyramax)는 말라리아(malaria) 치료용의 고정용량 복합제제(fixed-dose combination medication)이다.[2][3] 열대열말라리아원충(Plasmodium falciparum)과 삼일열말라리아원충(Plasmodium falciparum) 두 유형의 말라리아에 모두 사용된다.[3] 알테수네이트(artesunate)와 피로나리딘(pyronaridine)을 복합한 제제이다.[2] 경구용이다.[1]

두 약제의 혼합은 내성이 좋다.[3] 부작용은 두통, 구토, 기침 등이다.[3] 심각한 간 질환이나 신장 질환 환자에겐 사용을 권고하지 않는다.[1] 초기 임산부에게도 보통 사용을 권고하지 않는다.[1] 그러나 다른 선택지가 없고 치료가 산모의 생명을 구할 수 있을 것이라 예상되는 경우엔 사용한다.[1] 두 약제는 각각 다른 기전(mechanism)으로 작용한다.[1]

WHO 필수 의약품 목록(WHO Model List of Essential Medicines)에 올라 있다.[2]

이용

알테수네이트/피로나리딘(Artesunate/pyronaridine)은 열대열말라리아원충(Plasmodium falciparum)과 삼일열말라리아원충(Plasmodium falciparum) 두 유형의 말라리아에 모두 사용된다.[3] 심각한 증상에는 사용을 권고하지 않는다.[1]

2019년 한 리뷰에서는 알테메서/루메판트린(artemether/lumefantrine)에 비견될 만하다고 하였다.[4] 약효는 알테수네이트와 함께 메플로퀸(mefloquine)과도 비슷하다.[4] 말라리아 예방에는 사용을 권고하지 않는다.[1]

신약 재창출 연구

알테수네이트/피로나리딘이 코로나19 치료약으로 기능할 수 있는지를 검증하는 임상실험 연구를 진행할 가치가 충분하다는 체외(실험관내)(in vitro) 증거가 있다.[5]

같이 보기

각주

  1. ↑ 가 나 다 라 마 바 사 아 “Pyramax 180 mg/60 mg Film-coated tablet” (PDF). 《EMA》. 2017년 12월 14일에 원본 문서 (PDF)에서 보존된 문서. 2017년 12월 13일에 확인함. 
  2. ↑ 가 나 다 World Health Organization (2019). 《World Health Organization model list of essential medicines: 21st list 2019》. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO. 
  3. ↑ 가 나 다 라 마 “Application for inclusion in the WHO Model List of essential medicines” (PDF). 《WHO》. Nov 2010. 2017년 6월 29일에 확인함. 
  4. ↑ 가 나 Pryce J, Hine P (January 2019). “Pyronaridine-artesunate for treating uncomplicated Plasmodium falciparum malaria”. 《The Cochrane Database of Systematic Reviews》 1: CD006404. doi:10.1002/14651858.CD006404.pub3. PMC 6353203. PMID 30620055. 
  5. ↑ Krishna S, Augustin Y, Wang J, Xu C, Staines HM, Platteeuw H, Kamarulzaman A, Sall A, Kremsner P (January 2021). “Repurposing Antimalarials to Tackle the COVID-19 Pandemic”. 《Trends Parasitol》 37 (1): 8–11. doi:10.1016/j.pt.2020.10.003. PMC 7572038. PMID 33153922. 

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