시클로포스파미드

시클로포스파미드
체계적 명칭 (IUPAC 명명법)
(RS)-N,N-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
식별 정보
CAS 등록번호 50-18-0
ATC 코드 L01AA01
PubChem 2907
드러그뱅크 DB00531
ChemSpider 2804
화학적 성질
화학식 C7H15Cl2N2O2P 
분자량 261.086 g/mol
물리적 성질
녹는점 2 °C (36 °F)
약동학 정보
생체적합성 >75% (by mouth)
단백질 결합 >60%
동등생물의약품 ?
약물 대사 간
생물학적 반감기 3–12 hours
배출 콩팥
처방 주의사항
임부투여안전성 D(오스트레일리아)D(미국)
법적 상태
  • AU: S4 (처방전 필요)
  • CA: ℞-only
  • UK: POM (Prescription only)
  • US: ℞-only
  • In general: ℞ (Prescription only)
투여 방법 By mouth, by injection into a vein

시클로포스파미드(cyclophosphamide, CP, 다른 이름: cytophosphane 등)[1]는 화학요법으로서, 또 면역억제제로서 사용되는 약물이다.[2] 화학 요법으로서 림프종, 다발성 골수종, 백혈병, 난소암, 유방암, 소세포폐암, 신경모세포종, 육종을 치료하기 위해 사용된다.[2] 면역 억제제로서 신증후군, 다발성 맥관염 동반 육아종, 그리고 잇따르는 장기 이식 및 기타 질환에 사용된다.[2][3] 구강으로 또는 정맥 주사를 통해 투여된다.[2]

대부분의 사람들이 부작용을 겪는다.[2] 일반적인 부작용으로는 백혈구감소증, 식욕 부진, 구토, 탈모, 출혈성 방광염이 포함된다.[2] 그 밖의 심각한 부작용으로는 암, 불임, 알레르기, 폐섬유증의 위험성 증가이다.[2] 시클로포스파미드는 알킬화제 및 질소 머스터드계 약물에 속한다.[2] DNA 복제, RNA 생성을 간섭함으로써 동작하는 것으로 간주된다.[2]

시클로포스파미드는 1959년 미국에서 의학용으로 승인되었다.[2] 의료제도에 필수적인 가장 효과적이고 안전한 의약품 목록인 WHO 필수 의약품 목록에 등재되어 있다.[4] 개발도상국의 도매가는 1g 유리병 당 대략 US$3.65–14.30에 달한다.[5] 영국에서 이 정도와 동등한 복용량에 대한 비용은 NHS 기준 약 17.06 파운드이다.[6] 미국에서는 동일한 복용량으로 구강 기준으로 약 $19.56이다.[7]

각주

  1. ↑ “NCI Drug Dictionary”. 《National Cancer Institute》. 25 April 2015에 원본 문서에서 보존된 문서. 20 December 2016에 확인함. 
  2. ↑ 가 나 다 라 마 바 사 아 자 차 “Cyclophosphamide”. The American Society of Health-System Pharmacists. 2 January 2017에 원본 문서에서 보존된 문서. 8 December 2016에 확인함. 
  3. ↑ Pagnoux C (September 2016). “Updates in ANCA-associated vasculitis”. 《European Journal of Rheumatology》 3 (3): 122–133. doi:10.5152/eurjrheum.2015.0043. PMC 5058451. PMID 27733943. 
  4. ↑ “WHO Model List of Essential Medicines (19th List)” (PDF). 《World Health Organization》. April 2015. 13 December 2016에 원본 문서 (PDF)에서 보존된 문서. 8 December 2016에 확인함. 
  5. ↑ “Cyclophosphamide”. 《International Drug Price Indicator Guide》. 10 May 2017에 원본 문서에서 보존된 문서. 8 December 2016에 확인함. 
  6. ↑ 《British national formulary : BNF 69》 69판. British Medical Association. 2015. 580쪽. ISBN 9780857111562. 
  7. ↑ “NADAC as of 2016-12-07 | Data.Medicaid.gov”. 《Centers for Medicare and Medicaid Services》. 21 December 2016에 원본 문서에서 보존된 문서. 20 December 2016에 확인함. 

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