ディスオーダータンパク質が結合を行い機能を発揮する能力を有することは、タンパク質の構造安定性がこれらの能力の必要条件ではないことを示している。ディスオーダータンパク質には、short linear motifなどの短い機能的な部位が多くみられる。ディスオーダータンパク質とshort linear motifは、ヘンドラウイルス(英語版)、C型肝炎ウイルス、HIV-1、ヒトパピローマウイルスなど、多くのRNAウイルスに特に豊富にみられる。これらのウイルスは、このようなタンパク質やモチーフを利用して多数の宿主タンパク質との結合を促進し操作することで、自らのゲノムの情報量の限界を克服している[21][22]。
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