Interleukin-2

IL2
Struktur yang tersedia PDB Pencarian Ortolog: PDBe RCSB Daftar kode id PDB 1IRL, 1M47, 1M48, 1M49, 1M4A, 1M4B, 1M4C, 1NBP, 1PW6, 1PY2, 1QVN, 1Z92, 2B5I, 2ERJ, 3QAZ, 3QB1, 3INK, 4NEJ, 4NEM
Pengidentifikasi
Alias	IL2, IL-2, TCGF, lymphokine, interleukin 2
ID eksternal	OMIM: 147680 MGI: 96548 HomoloGene: 488 GeneCards: IL2
Lokasi gen (Tikus) Kr. Kromosom 3 (tikus)[1] Pita 3 B|3 18.3 cM Awal 37,174,672 bp[1] Akhir 37,180,108 bp[1]
Pola ekspresi RNA Referensi data ekspresi selengkapnya
Ontologi gen Fungsi molekuler • cytokine activity • interleukin-2 receptor binding • glycosphingolipid binding • kinase activator activity • growth factor activity • kappa-type opioid receptor binding • carbohydrate binding • GO:0001948, GO:0016582 Ikatan protein plasma Komponen seluler • extracellular region • intracellular anatomical structure • extracellular space Proses biologis • positive regulation of T cell differentiation • GO:0033128 negative regulation of protein phosphorylation • G protein-coupled receptor signaling pathway • positive regulation of protein phosphorylation • positive regulation of inflammatory response • adaptive immune response • negative regulation of heart contraction • immune system process • positive regulation of cytosolic calcium ion concentration • positive regulation of regulatory T cell differentiation • cell-cell signaling • positive regulation of interferon-gamma production • natural killer cell activation • negative regulation of apoptotic process • positive regulation of dendritic spine development • negative regulation of lymphocyte proliferation • MAPK cascade • regulation of T cell homeostatic proliferation • T cell differentiation • positive regulation of cell growth • protein kinase C-activating G protein-coupled receptor signaling pathway • Adhesi sel • positive regulation of B cell proliferation • positive regulation of tissue remodeling • positive regulation of T cell proliferation • GO:0046730, GO:0046737, GO:0046738, GO:0046736 respons imun • positive regulation of cell population proliferation • extrinsic apoptotic signaling pathway in absence of ligand • negative regulation of B cell apoptotic process • positive regulation of isotype switching to IgG isotypes • positive regulation of interleukin-17 production • response to ethanol • negative regulation of inflammatory response • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of activated T cell proliferation • negative regulation of T-helper 17 cell differentiation • leukocyte activation involved in immune response • positive regulation of tyrosine phosphorylation of STAT protein • regulation of regulatory T cell differentiation • regulation of signaling receptor activity • cytokine-mediated signaling pathway • interleukin-2-mediated signaling pathway • positive regulation of kinase activity Sumber:Amigo / QuickGO
Ortolog
Spesies	Manusia	Tikus
Entrez	3558	16183
Ensembl	ENSG00000109471	ENSMUSG00000027720
UniProt	P60568	P04351
RefSeq (mRNA)	NM_000586	NM_008366
RefSeq (protein)	NP_000577	NP_032392
Lokasi (UCSC)	n/a	Chr 3: 37.17 – 37.18 Mb
Pencarian PubMed	[2]	[3]
Wikidata
Lihat/Sunting Manusia Lihat/Sunting Tikus

Interleukin-2, IL-2 (bahasa Inggris: T Cell Growth Factor, TCGF, lymphokine) adalah sejenis sitokina yang disebut hormon leukositotropik,^[4] yang berperan sebagai stimulan dalam proliferasi sel B dan sel T.^[5]

IL-2 ditelisik mempunyai fungsi yang serupa dengan IL-15.^[6] IL-2 berperan dalam apoptosis sel T yang teraktivasi bukan oleh antigen, hal ini penting untuk mencegah autoimunitas, sedangkan IL-15 berperan dalam pemeliharaan sel T memori.^[6]

Rujukan

1. GRCm38: Ensembl release 89: ENSMUSG00000027720 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. (Inggris) "Interleukin-2: inception, impact, and implications". Dartmouth Medical School; Smith KA. Diakses tanggal 2010-06-07.
5. (Inggris) "IL2 interleukin 2 [ Homo sapiens ]". Entrez Gene. Diakses tanggal 2010-06-07.
6. (Inggris) "The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design". Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Waldmann TA. Diakses tanggal 2010-06-07.