Kreatiinikinaasi

Kiteytettyjä jäniksen kreatikiinikinaasientsyymimolekyylejä

Kreatiinikinaasi eli kreatiinifosfokinaasi eli CK on entsyymi, jota on erityisesti lihaksissa ja keskushermostossa[1]. Entsyymi katalysoi kreatiinin ja adenosiinitrifosfaatin reaktiota fosfokreatiiniksi ja adenosiinidifosfaatiksi. Se katalysoi niin ikään tälle käänteistä reaktiota.[2]

Olosuhteet

Kreatiinikinaasin massa vaihtelee eliöstä riippuen 42–371 kilodaltonin välillä. Toimiakseen kunnolla entsyymiin täytyy olla kiinnittyneenä magnesiumioneja ja ihmisellä lisäksi myös mangaania. Entsyymin toimintaa haittaavat halogeenien anionit, tiettyjen metallien kuten kuparin ionit ja useat orgaaniset molekyylit kuten 4-hydroksinonenaali, etyylimalonihappo ja jodiasetamidi. Parhaiten kreatiinikinaasi toimii lämpötilan ollessa eliöstä riippuen 0,5–45 °C ja pH:n ollessa 6–9.[2]

Kreatiinikinaasi ja sairaudet

Kreatiinikinaasitaso on korkealla fyysisten suoritusten jälkeen. Korkeita kreatiinikinaasipitoisuuksia tavataan myös lihasdystrofiaa, myosiittia ja sydänlihastulehdusta sairastavilla.[1] Korkea entsyymitaso voi olla myös merkki tukoksesta sepelvaltimossa.[3]

Matala kreatiinikinaasitaso voi olla merkki alkoholin aiheuttamasta maksasairaudesta tai nivelreumasta.[4]

Lähteet

  1. ↑ a b Kreatiinikinaasi Yhtyneet laboratoriot oy. Arkistoitu 26.3.2004. Viitattu 20.1.2009.
  2. ↑ a b EC 2.7.3.2 - creatine kinase brenda-enzymes.info. Brenda. Viitattu 20.1.2009. (englanniksi)
  3. ↑ Kreatiinikinaasi Duodecim. Viitattu 20.1.2009.
  4. ↑ Creatine kinase CreatineJournal. Viitattu 20.1.2009. (englanniksi)
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