UDP-N-acetylglucosamine kinase

UDP-N-acetylglucosamine kinase
Identifiers
EC no.	2.7.1.176
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

UDP-N-acetylglucosamine kinase (EC 2.7.1.176, UNAG kinase, zeta toxin, toxin PezT, ATP:UDP-N-acetyl-D-glucosamine 3'-phosphotransferase) is an enzyme with systematic name ATP:UDP-N-acetyl-alpha-D-glucosamine 3'-phosphotransferase.^[1][2] This enzyme catalyses the following chemical reaction

ATP + UDP-N-acetyl-alpha-D-glucosamine ${\displaystyle \rightleftharpoons }$ ADP + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate

The phosphorylation of UDP-N-acetyl-D-glucosamine causes the inhibition of enzyme EC 2.5.1.7, UDP-N-acetylglucosamine 1-carboxyvinyltransferase.

These enzymes are found as part of plasmid-encoded^[3] and chromosomal^[4] bacterial toxin-antitoxin systems.

References

1. Mutschler H, Gebhardt M, Shoeman RL, Meinhart A (March 2011). "A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis". PLOS Biology. 9 (3): e1001033. doi:10.1371/journal.pbio.1001033. PMC 3062530. PMID 21445328.
2. Rocker A, Meinhart A (August 2015). "A cis-acting antitoxin domain within the chromosomal toxin-antitoxin module EzeT of Escherichia coli quenches toxin activity". Molecular Microbiology. 97 (3): 589–604. doi:10.1111/mmi.13051. PMID 25943309.
3. Zielenkiewicz U, Ceglowski P (September 2005). "The toxin-antitoxin system of the streptococcal plasmid pSM19035". Journal of Bacteriology. 187 (17): 6094–105. doi:10.1128/JB.187.17.6094-6105.2005. PMC 1196172. PMID 16109951.
4. Khoo SK, Loll B, Chan WT, Shoeman RL, Ngoo L, Yeo CC, Meinhart A (July 2007). "Molecular and structural characterization of the PezAT chromosomal toxin-antitoxin system of the human pathogen Streptococcus pneumoniae". The Journal of Biological Chemistry. 282 (27): 19606–18. doi:10.1074/jbc.m701703200. hdl:11858/00-001M-0000-002C-A8AD-E. PMID 17488720.

External links

• UDP-N-acetylglucosamine+kinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)