UDP-N-acetylgalactosamine diphosphorylase

UDP-N-acetylgalactosamine diphosphorylase
Identifiers
EC no.	2.7.7.83
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

UDP-N-acetylgalactosamine diphosphorylase (EC 2.7.7.83) is an enzyme with systematic name UTP:N-acetyl-alpha-D-galactosamine-1-phosphate uridylyltransferase.^[1][2] This enzyme catalyses the following chemical reaction

UTP + N-acetyl-alpha-D-galactosamine 1-phosphate ${\displaystyle \rightleftharpoons }$ diphosphate + UDP-N-acetyl-alpha-D-galactosamine

The enzyme from plants and animals also acts on N-acetyl-alpha-D-glucosamine 1-phosphate.

References

1. Wang-Gillam A, Pastuszak I, Elbein AD (October 1998). "A 17-amino acid insert changes UDP-N-acetylhexosamine pyrophosphorylase specificity from UDP-GalNAc to UDP-GlcNAc". The Journal of Biological Chemistry. 273 (42): 27055–7. doi:10.1074/jbc.273.42.27055. PMID 9765219.
2. Peneff C, Ferrari P, Charrier V, Taburet Y, Monnier C, Zamboni V, Winter J, Harnois M, Fassy F, Bourne Y (November 2001). "Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture". The EMBO Journal. 20 (22): 6191–202. doi:10.1093/emboj/20.22.6191. PMC 125729. PMID 11707391.

External links

• UDP-N-acetylgalactosamine+diphosphorylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)