Togavirus 5′ plus strand cis-regulatory element

Togavirus 5′ plus strand cis-regulatory element
Predicted secondary structure and sequence conservation of Toga_5_CRE
Identifiers
Symbol	Toga_5_CRE
Rfam	RF00470
Other data
RNA type	Cis-reg
Domain(s)	Viruses
SO	SO:0000233
PDB structures	PDBe

The Togavirus 5′ plus strand cis-regulatory element is an RNA element which is thought to be essential for both plus and minus strand RNA synthesis.^[1]

Genus Alphavirus belongs to the family Togaviridae. Alpha viruses contain secondary structural motifs in the 5′ UTR that allow them to avoid detection by IFIT1.^[2]

See also

• Rubella virus 3′ cis-acting element

References

1. Frolov I, Hardy R, Rice CM (November 2001). "Cis-acting RNA elements at the 5′ end of Sindbis virus genome RNA regulate minus- and plus-strand RNA synthesis". RNA. 7 (11): 1638–1651. doi:10.1017/S135583820101010X. PMC 1370205. PMID 11720292.
2. Hyde JL, Gardner CL, Kimura T, White JP, Liu G, Trobaugh DW, Huang C, Tonelli M, Paessler S, Takeda K, Klimstra WB, Amarasinghe GK, Diamond MS (February 2014). "A viral RNA structural element alters host recognition of nonself RNA". Science. 343 (6172): 783–787. doi:10.1126/science.1248465. PMC 4209899. PMID 24482115.

External links

• Page for Togavirus 5′ plus strand cis-regulatory element at Rfam