Set between 1629 and 1631, the adaptation tells the story of Renzo Tramaglino and Lucia Mondella, Lombard commoners forced to separate and endure a thousand vicissitudes due to the arrogance of the lord Don Rodrigo. However, during their journey they will find various people willing to help them, from Fra Cristoforo to the Innominato (first cruel and then converted), from Federigo Borromeo to Donna Prassede.