Sodium-dependent phosphate transport protein 1

SLC17A1
Identifiers
Aliases	SLC17A1, NAPI-1, NPT-1, NPT1, solute carrier family 17 member 1
External IDs	OMIM: 182308; MGI: 103209; HomoloGene: 48324; GeneCards: SLC17A1; OMA:SLC17A1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.2 Start 25,782,915 bp[1] End 25,832,052 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 A3.1|13 9.97 cM Start 24,051,733 bp[2] End 24,079,713 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver kidney tubule renal cortex metanephric glomerulus renal medulla islet of Langerhans human kidney left testis right testis mucosa of transverse colon Top expressed in right kidney human kidney proximal tubule left lobe of liver neural layer of retina epithelium of lens retinal pigment epithelium primary visual cortex stroma of bone marrow duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sodium:phosphate symporter activity phosphate ion transmembrane transporter activity symporter activity sialic acid transmembrane transporter activity Cellular component integral component of membrane integral component of plasma membrane membrane plasma membrane apical plasma membrane lysosome Biological process phosphate ion transport phosphate ion transmembrane transport ion transport sodium ion transmembrane transport urate metabolic process sodium ion transport transmembrane transport sodium-dependent phosphate transport urate transport sialic acid transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6568 20504 Ensembl ENSG00000124568 ENSMUSG00000021335 UniProt Q14916 Q61983 RefSeq (mRNA) NM_005074 NM_001170638 NM_009198 RefSeq (protein) NP_005065 NP_001164109 NP_033224 Location (UCSC) Chr 6: 25.78 – 25.83 Mb Chr 13: 24.05 – 24.08 Mb PubMed search [3] [4]
Wikidata
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Sodium-dependent phosphate transport protein 1 is a protein that in humans is encoded by the SLC17A1 gene.^[5][6]

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000124568 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021335 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chong SS, Kristjansson K, Zoghbi HY, Hughes MR (Feb 1994). "Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23". Genomics. 18 (2): 355–9. doi:10.1006/geno.1993.1476. PMID 8288239.
6. "Entrez Gene: SLC17A1 solute carrier family 17 (sodium phosphate), member 1".

Further reading

• Miyamoto K, Tatsumi S, Sonoda T, et al. (1995). "Cloning and functional expression of a Na(+)-dependent phosphate co-transporter from human kidney: cDNA cloning and functional expression". Biochem. J. 305 (1): 81–5. doi:10.1042/bj3050081. PMC 1136432. PMID 7826357.
• Li H, Xie Z (1997). "Molecular cloning of two rat Na+/Pi cotransporters: evidence for differential tissue expression of transcripts". Cell. Mol. Biol. Res. 41 (5): 451–60. PMID 8867793.
• Taketani Y, Miyamoto K, Chikamori M, et al. (1998). "Characterization of the 5' flanking region of the human NPT-1 Na+/phosphate cotransporter gene". Biochim. Biophys. Acta. 1396 (3): 267–72. doi:10.1016/s0167-4781(97)00231-5. PMID 9545579.
• Totaro A, Roetto A, Rommens JM, et al. (1998). "Generation of a transcription map of a 1 Mbase region containing the HFE gene (6p22)". Eur. J. Hum. Genet. 6 (2): 105–13. doi:10.1038/sj.ejhg.5200162. PMID 9781053.
• Uchino H, Tamai I, Yamashita K, et al. (2000). "p-aminohippuric acid transport at renal apical membrane mediated by human inorganic phosphate transporter NPT1". Biochem. Biophys. Res. Commun. 270 (1): 254–9. doi:10.1006/bbrc.2000.2407. PMID 10733936.
• Soumounou Y, Gauthier C, Tenenhouse HS (2001). "Murine and human type I Na-phosphate cotransporter genes: structure and promoter activity". Am. J. Physiol. Renal Physiol. 281 (6): F1082–91. doi:10.1152/ajprenal.0092.2001. PMID 11704559.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gisler SM, Pribanic S, Bacic D, et al. (2004). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.