SLC45A4

SLC45A4
Identifiers
Aliases	SLC45A4, solute carrier family 45 member 4
External IDs	MGI: 2146236; HomoloGene: 69908; GeneCards: SLC45A4; OMA:SLC45A4 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.3 Start 141,207,166 bp[1] End 141,308,305 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D3 Start 73,449,273 bp[2] End 73,517,611 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell endothelial cell blood retinal pigment epithelium postcentral gyrus Brodmann area 23 middle temporal gyrus primary visual cortex Achilles tendon bronchial epithelial cell Top expressed in submandibular gland Epithelium of choroid plexus retinal pigment epithelium facial motor nucleus vastus lateralis muscle molar triceps brachii muscle extraocular muscle vestibular membrane of cochlear duct olfactory epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function sucrose:proton symporter activity Cellular component membrane integral component of membrane Biological process sucrose transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57210 106068 Ensembl ENSG00000022567 ENSMUSG00000079020 UniProt Q5BKX6 Q0P5V9 RefSeq (mRNA) NM_001080431 NM_001286646 NM_001286648 NM_001033219 NM_001168255 NM_001357747 RefSeq (protein) NP_001073900 NP_001273575 NP_001273577 NP_001028391 NP_001161727 NP_001344676 Location (UCSC) Chr 8: 141.21 – 141.31 Mb Chr 15: 73.45 – 73.52 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SLC45A4 is a member of the SLC45 family of solute carriers. Analysis of the protein function in a recombinant yeast expression assay show that it can: (i) transport a disaccharide, sucrose, as well simple sugars such as glucose and fructose (ii) perform secondary active transport in a proton-dependent manner.^[5]

It is associated with sugar transport in the spermatozoa.^[6] Additionally, it has been identified as a necessary component in the cell death caused of the compound paraquat.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000022567 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000079020 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bartölke R, Heinisch JJ, Wieczorek H, Vitavska O (December 2014). "Proton-associated sucrose transport of mammalian solute carrier family 45: an analysis in Saccharomyces cerevisiae". The Biochemical Journal. 464 (2): 193–201. doi:10.1042/BJ20140572. PMID 25164149.
6. Vitavska O, Wieczorek H (November 2017). "+/sugar cotransporter in mammalian spermatozoa". Pflügers Archiv. 469 (11): 1433–1442. doi:10.1007/s00424-017-2024-9. PMC 5629229. PMID 28689241.
7. Reczek CR, Birsoy K, Kong H, Martínez-Reyes I, Wang T, Gao P, et al. (December 2017). "A CRISPR screen identifies a pathway required for paraquat-induced cell death". Nature Chemical Biology. 13 (12): 1274–1279. doi:10.1038/nchembio.2499. PMC 5698099. PMID 29058724.