RRNA (guanine-N2-)-methyltransferase

rRNA (guanine-N2-)-methyltransferase
Identifiers
EC no.	2.1.1.52
CAS no.	50812-26-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a rRNA (guanine-N2-)-methyltransferase (EC 2.1.1.52) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + rRNA ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + rRNA containing N₂-methylguanine

Thus, the two substrates of this enzyme are S-adenosyl methionine and rRNA, whereas its two products are S-adenosylhomocysteine and rRNA containing N2-methylguanine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:rRNA (guanine-N2-)-methyltransferase. Other names in common use include ribosomal ribonucleate guanine-2-methyltransferase, and S-adenosyl-L-methionine:rRNA (guanine-2-N-)-methyltransferase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2PJD.

References

• Isaksson LA (June 1973). "Partial purification of ribosomal RNA(m1G)- and rRNA(m2G)-methylases from Escherichia coli and demonstration of some proteins affecting their apparent activity". Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis. 312 (1): 122–33. doi:10.1016/0005-2787(73)90057-9. PMID 4580201.