Quantitative insulin sensitivity check index

The quantitative insulin sensitivity check index (QUICKI) is derived using the inverse of the sum of the logarithms of the fasting insulin and fasting glucose:

1 / (log(fasting insulin μU/mL) + log(fasting glucose mg/dL))

This index correlates well with glucose clamp studies (r = 0.78), and is useful for measuring insulin sensitivity (IS), which is the inverse of insulin resistance (IR). It has the advantage of that it can be obtained from a fasting blood sample, and is the preferred method for certain types of clinical research.

There are no documented reference value for QUICKI.^[1] In one study, 95% of healthy persons had a QUICKI index above 0.357.^[2] Another study concluded that QUICKI index 0.3469 or below should be used to determine insulin resistance.^[3]

See also

• SPINA-GBeta
• SPINA-GR
• Homeostatic model assessment

References

1. Tohidi, Maryam; Ghasemi, Asghar; Hadaegh, Farzad; Derakhshan, Arash; Chary, Abdolreza; Azizi, Fereidoun (2014). "Age- and sex-specific reference values for fasting serum insulin levels and insulin resistance/sensitivity indices in healthy Iranian adults: Tehran Lipid and Glucose Study". Clinical Biochemistry. 47 (6): 432–438. doi:10.1016/j.clinbiochem.2014.02.007. PMID 24530467.
2. Hřebíček, Jiří; Janout, Vladimír; Malinčíková, Jana; Horáková, Dagmar; Čížek, Luděk (2002-01-01). "Detection of Insulin Resistance by Simple Quantitative Insulin Sensitivity Check Index QUICKI for Epidemiological Assessment and Prevention". The Journal of Clinical Endocrinology & Metabolism. 87 (1): 144–147. doi:10.1210/jcem.87.1.8292. ISSN 0021-972X. PMID 11788638.
3. Gokcel, A.; Baltali, M.; Tarim, E.; Bagis, T.; Gumurdulu, Y.; Karakose, H.; Yalcin, F.; Akbaba, M.; Guvener, N. (2003). "Detection of insulin resistance in Turkish adults: a hospital-based study: Detection of insulin resistance in Turkish adults". Diabetes, Obesity and Metabolism. 5 (2): 126–130. doi:10.1046/j.1463-1326.2003.00253.x. PMID 12630938. S2CID 46611787.

Sources

• Katz, Arie; Nambi, Sridhar S.; Mather, Kieren; Baron, Alain D.; Follmann, Dean A.; Sullivan, Gail; Quon, Michael J. (2000-07-01). "Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans". The Journal of Clinical Endocrinology & Metabolism. 85 (7): 2402–2410. doi:10.1210/jcem.85.7.6661. ISSN 0021-972X. PMID 10902785.
• Source as above - Katz et al. Also data for unusually healthy individuals derived from those practicing caloric restriction. See CR Society for details.