Psoralen synthase

Psoralen synthase
Identifiers
EC no.	1.14.13.102
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

In enzymology, a psoralen synthase (EC 1.14.13.102) is an enzyme that catalyzes the chemical reaction

(+)-marmesin + NADPH + H⁺ + O₂ ${\displaystyle \rightleftharpoons }$ psoralen + NADP⁺ + acetone + 2 H₂O

The 4 substrates of this enzyme are (+)-marmesin, NADPH, H⁺, and O₂, whereas its 4 products are psoralen, NADP⁺, acetone, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O₂ as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O₂ with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is (?). This enzyme is also called CYP71AJ1.

References

• Larbat R, Kellner S, Specker S, Hehn A, Gontier E, Hans J, Bourgaud F, Matern U (January 2007). "Molecular cloning and functional characterization of psoralen synthase, the first committed monooxygenase of furanocoumarin biosynthesis" (PDF). The Journal of Biological Chemistry. 282 (1): 542–54. doi:10.1074/jbc.M604762200. PMID 17068340.