On 27 October 2021, CEO Chatri Sityodtong broke the news that ONE: X would be postponed to early 2022, owing to a recent surge in the COVID-19 pandemic in Singapore.[2] The event was later rescheduled for March 26, 2022.
Top Filipino strawweights Lito Adiwang and Jeremy Miado faced each other at this event.[8] A rematch between Seo Hee Ham and Denice Zamboanga was also booked for the event.[9] A featherweight fight between Amir Khan and Ryogo Takahashi was added to the ONE: X card.[10]
Reinier de Ridder and Andre Galvao met in a submission grappling match.[11] The American Danielle Kelly made her debut at ONE X in an atomweight submission grappling match against Japanese veteran Mei Yamaguchi.[12]
Nieky Holzken was scheduled to face Islam Murtazaev in a fight between two top lightweight Kickboxing contenders.[13] Shoko Sato was to meet Yusup Saadulaev in a battle of formerly ranked bantamweight contenders. The card also featured Ryuto Sawada and Senzo Ikeda, who meet in a strawweight contest.[14] However, due to the 2022 Russian invasion of Ukraine, all Russian athletes were removed from the card as a result of the Singaporean government banning them from entering the country. As a result, Murtazaev was replaced by Sinsamut Klinmee and Yusup Saadulaev was replaced by Stephen Loman.[15][16][17]
Alyse Anderson was scheduled to fight with Indian striker Asha Roka.[18] However, Anderson withdraw from the bout for medical reasons and the fight was rescheduled for ONE 157.[19]