O'Driscoll was drafted with Fremantle's second selection, the 27th overall, in the 2020 national draft.[1]
2022: Debut Season
After not playing any AFL games in 2021, he made his AFL debut as the medical substitute for Fremantle in round 2 of the 2022 AFL season against St Kilda. He entered the game in the final quarter after Sean Darcy injured his ankle[2] and kicked a spectacular goal with his first kick from near the boundary line.[3] He received his first Goal of the Year nomination in round 8 against the North Melbourne Kangaroos with an incredible set shot drop punt from the left pocket.[4] O'Driscoll was sidelined prior to round 9 due to a stress fracture in his foot.[5]
Nathan returned to the line-up for Fremantle in the round 21 clash against the Western Bulldogs. O'Driscoll earned the defining moment of the game in which he received the ball just outside of centre square before outpacing Western Bulldogs vice captain Jack Macrae and kicking a goal from the 50-metre arc.[6] He finished the game having earnt his second Goal of the Year nomination. O'Driscoll received a 2022 AFL Rising Star nomination for his performance in round 23 against Greater Western Sydney at Manuka Oval in Canberra. He finished with 2 goals, 17 disposals, five inside 50s, five clearances and four tackles in the 20 point win.[7]
2023 - 2024
O'Driscoll signed a two-year contract extension at the end of the 2024 AFL season to remain at Fremantle until at least 2026.[8]
His older sister, Emma O'Driscoll also plays for Fremantle in the AFLW.[9] His younger brother, Aiden O'Driscoll, was drafted to the Western Bulldogs for the 2024 AFL season but medically retired on 14 May 2024 without playing a game after suffering a head injury during the preseason.[10][11]