On 1 June 2009, he parted ways with Cholet.[4] On 25 June 2009, he was selected with the 53rd overall pick in the 2009 NBA draft by the San Antonio Spurs.
On 13 July 2009, he signed a three-year deal with Valencia of Spain.[5] He went on to win the 2010 EuroCup title with Valencia.
San Antonio Spurs
On 10 July 2012, De Colo announced he would not be re-signing with Valencia in order to play in the NBA.[6] On 13 July 2012, he signed a two-year deal with the San Antonio Spurs.[7] During his rookie and sophomore seasons, he had multiple assignments with the Austin Toros of the NBA D-League. De Colo reached the 2013 NBA Finals with the Spurs, but the team lost to the Miami Heat in seven games.[8][9]
In the 2014–15 season, CSKA Moscow managed to advance to the EuroLeague Final Four, for the fourth straight season, after eliminating Panathinaikos for the second straight season in the EuroLeague quarterfinals playoffs series, with a 3–1 series victory.[14] However, in the EuroLeague Final Four's semi-final game, despite being dubbed by the media as an absolute favorite to advance to the Finals, CSKA once again lost to Olympiacos. The final score was 70–68, after a great Olympiacos comeback in the 4th quarter, which was led by Vassilis Spanoulis.[15] CSKA Moscow eventually won the third place game, after defeating Fenerbahçe, by a score of 86–80.[16] In his second EuroLeague season, De Colo averaged a career-high 14.4 points, 3.2 rebounds, and 3.1 assists per game, over 28 games played. On 21 May 2015, De Colo won the VTB United League MVP Award.[17] CSKA Moscow finished the season by winning the VTB United League championship, after eliminating Khimki, with a 3–0 series sweep in the league's finals series.[18]
In the 2018–19 season, De Colo won his second EuroLeague title with CSKA after defeating Anadolu Efes in the championship game of the Final Four. Moscow also went on to win the VTB United League once again, making it his fifth league title.
Fenerbahçe
On July 6, 2019, de Colo signed with Fenerbahçe of the Turkish Basketball Super League and the EuroLeague, on a 2+1 deal.[26] On October 19, 2019, de Colo set personal career-high with 39 points in a EuroLeague win over Baskonia.[27] In his first season with the club, he averaged 15.9 points, 3 rebounds and 3 assists over 24 EuroLeague games. The season was cut short due to COVID-19 pandemic.
In 2020–21 season, over 32 EuroLeague games, de Colo averaged 15.8 points, 3.9 assists and 3.2 rebounds per game. In December 2021, he suffered a fracture in the second metacarpal bone of his left hand, which will keep him off the court for weeks after surgery is performed.[28]
De Colo played internationally at the 2012 London Olympics. He played a major role on the French team during the tournament. He also displayed strong offense and defense, as he scored seven points in their game against the United States.