The enzyme N-sulfoglucosamine-3-sulfatase (EC 3.1.6.15}) catalyzes cleaving off the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin.[1][2]
This enzyme belongs to the family of hydrolases, specifically those acting on sulfuric ester bonds. The systematic name is N-sulfo-3-sulfoglucosamine 3-sulfohydrolase. This enzyme is also called chondroitinsulfatase. This enzyme participates in the degradation of glycan structures.
References
^Bruce JS, McLean MW, Long WF, Williamson FB (1985). "Flavobacterium heparinum 3-O-sulphatase for N-substituted glucosamine 3-O-sulphate". Eur. J. Biochem. 148 (2): 359–65. doi:10.1111/j.1432-1033.1985.tb08847.x. PMID3987694.
^Leder IG (1980). "A novel 3-O sulfatase from human urine acting on methyl-2-deoxy-2-sulfamino-alphs-D-glucopyranoside 3-sulfate". Biochem. Biophys. Res. Commun. 94 (4): 1183–9. doi:10.1016/0006-291X(80)90544-6. PMID7396957.
