N-acetylmuramic acid 6-phosphate etherase

N-acetylmuramic acid 6-phosphate etherase
Identifiers
EC no.	4.2.1.126
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

N-acetylmuramic acid 6-phosphate etherase (EC 4.2.1.126, MurNAc-6-P etherase, MurQ) is an enzyme with systematic name (R)-lactate hydro-lyase (adding N-acetyl-D-glucosamine 6-phosphate; N-acetylmuramate 6-phosphate-forming).^{[1][2][3][4][5]} This enzyme catalyses the following chemical reaction

(R)-lactate + N-acetyl-D-glucosamine 6-phosphate ${\displaystyle \rightleftharpoons }$ N-acetylmuramate 6-phosphate + H₂O

This enzyme is required for the utilization of anhydro-N-acetylmuramic acid in some Pseudomonadota.

References

1. Jaeger T, Arsic M, Mayer C (August 2005). "Scission of the lactyl ether bond of N-acetylmuramic acid by Escherichia coli "etherase"". The Journal of Biological Chemistry. 280 (34): 30100–6. doi:10.1074/jbc.m502208200. PMID 15983044.
2. Uehara T, Suefuji K, Valbuena N, Meehan B, Donegan M, Park JT (June 2005). "Recycling of the anhydro-N-acetylmuramic acid derived from cell wall murein involves a two-step conversion to N-acetylglucosamine-phosphate". Journal of Bacteriology. 187 (11): 3643–9. doi:10.1128/jb.187.11.3643-3649.2005. PMC 1112033. PMID 15901686.
3. Uehara T, Suefuji K, Jaeger T, Mayer C, Park JT (February 2006). "MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall". Journal of Bacteriology. 188 (4): 1660–2. doi:10.1128/jb.188.4.1660-1662.2006. PMC 1367226. PMID 16452451.
4. Hadi T, Dahl U, Mayer C, Tanner ME (November 2008). "Mechanistic studies on N-acetylmuramic acid 6-phosphate hydrolase (MurQ): an etherase involved in peptidoglycan recycling". Biochemistry. 47 (44): 11547–58. doi:10.1021/bi8014532. PMID 18837509.
5. Jaeger T, Mayer C (March 2008). "N-acetylmuramic acid 6-phosphate lyases (MurNAc etherases): role in cell wall metabolism, distribution, structure, and mechanism". Cellular and Molecular Life Sciences. 65 (6): 928–39. doi:10.1007/s00018-007-7399-x. PMC 11131651. PMID 18049859.

External links

• N-acetylmuramic+acid+6-phosphate+etherase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)