N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase

N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase
Identifiers
EC no.	2.4.1.226
CAS no.	269077-98-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase (EC 2.4.1.226) is an enzyme that catalyzes the chemical reaction

UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl- proteoglycan ${\displaystyle \rightleftharpoons }$ UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)- beta-D-glucuronosyl-proteoglycan

The 3 substrates of this enzyme are UDP-alpha-D-glucuronate, [[N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-]], and proteoglycan, whereas its 3 products are UDP, [[beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-]], and beta-D-glucuronosyl-proteoglycan.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glu curonosyl-proteoglycan 3-beta-glucuronosyltransferase. This enzyme is also called chondroitin glucuronyltransferase II. This enzyme participates in chondroitin sulfate biosynthesis and glycan structures - biosynthesis 1.

References

• Kitagawa H, Uyama T, Sugahara K (2001). "Molecular cloning and expression of a human chondroitin synthase". J. Biol. Chem. 276 (42): 38721–6. doi:10.1074/jbc.M106871200. PMID 11514575.
• DeAngelis PL, Padgett-McCue AJ (2000). "Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F". J. Biol. Chem. 275 (31): 24124–9. doi:10.1074/jbc.M003385200. PMID 10818104.
• Ninomiya T, Sugiura N, Tawada A, Sugimoto K, Watanabe H, Kimata K (2002). "Molecular cloning and characterization of chondroitin polymerase from Escherichia coli strain K4". J. Biol. Chem. 277 (24): 21567–75. doi:10.1074/jbc.M201719200. PMID 11943778.
• N, Togayachi A, Kudo T, Watanabe H, Kimata K, Narimatsu H (2002). "Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N-acetylgalactosamine". J. Biol. Chem. 277 (41): 38179–88. doi:10.1074/jbc.M202601200. PMID 12145278.