Microtubule-severing ATPase

microtubule-severing ATPase
Identifiers
EC no.	3.6.4.3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a microtubule-severing ATPase (EC 3.6.4.3) is an enzyme that catalyzes the chemical reaction

ATP + H₂O ${\displaystyle \rightleftharpoons }$ ADP + phosphate

Thus, the two substrates of this enzyme are ATP and H₂O, whereas its two products are ADP and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to facilitate cellular and subcellular movement. The systematic name of this enzyme class is ATP phosphohydrolase (tubulin-dimerizing).

See also

• Katanin

References

• McNally FJ, Vale RD (1993). "Identification of katanin, an ATPase that severs and disassembles stable microtubules". Cell. 75 (3): 419–29. doi:10.1016/0092-8674(93)90377-3. PMID 8221885.
• Cheesman S, Heuser J, Vale RD, McNally FJ (1998). "Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit". Cell. 93 (2): 277–87. doi:10.1016/S0092-8674(00)81578-0. PMID 9568719.