A total of sixty-four players have made their Australian Football League (AFL) debut in a senior AFL match to date during the 2010 AFL season. In addition to those players making their AFL-level debuts, twenty-eight players have made their debuts following a trade or re-drafting are also listed below in a separate table.
A senior AFL match is an Australian rules football match between two clubs that are, or have been in the past, members of the AFL. A senior AFL match is played under the laws of Australian football, and includes regular season matches, as well as finals series matches. It does not include pre-season competition matches, interstate matches or international rules football matches. The list is arranged in the order in which each player made his debut for a club in a senior AFL match. Where more than one player made his debut in the same match, those players are listed alphabetically by surname.