Lerdelimumab
Monoclonal antibody
Pharmaceutical compound
Lerdelimumab (CAT-152 , intended trade name Trabio ) is a human monoclonal antibody and an immunosuppressive drug targeting TGF beta 2 .
It was being developed to reduce scarring after glaucoma drainage surgery .[ 1] Development was stopped in late 2005 after unsuccessful trial results for that condition.[ 2]
References
Intracellular (initiation)
Intracellular (reception)
Extracellular
Unsorted
Type I
ALK1 (ACVRL1 )ALK2 (ACVR1A )ALK3 (BMPR1A )ALK4 (ACVR1B )ALK5 (TGFβR1 )ALK6 (BMPR1B )
Agonists: BMP (2 , 4 , 5 , 6 , 7 , 8A , 8B , 15 (GDF9B) )
Dibotermin alfa
Eptotermin alfa
GDF (5 (BMP14) , 6 (BMP13) , 7 (BMP12) , 9 , 15 )
Radotermin
ALK7 (ACVR1C )
Type II
TGFβR2 BMPR2 ACVR2A (ACVR2 )
Agonists: Activin (A , B , AB )
BMP (2 , 4 , 5 , 6 , 7 , 8A , 8B , 15 (GDF9B) )
Dibotermin alfa
Eptotermin alfa
GDF (1 , 3 , 5 (BMP14) , 6 (BMP13) , 7 (BMP12) , 9 , 11 (BMP11) , 15 )
Myostatin (GDF8)
Nodal
Radotermin
ACVR2B
Agonists: Activin (A , B , AB )
BMP (2 , 4 , 6 , 7 )
Dibotermin alfa
Eptotermin alfa
GDF (1 , 3 , 5 (BMP14) , 6 (BMP13) , 7 (BMP12) )
Myostatin (GDF8)
Nodal
Osteogenin (BMP3, BMP3A)
Radotermin
AMHR2 (AMHR )
Type III
Unsorted