Left-right determination factor 2

7044

Left-right determination factor 2
LEFTY2
Identifiers
AliasesLEFTY2, EBAF, LEFTA, LEFTYA, TGFB4, left-right determination factor 2
External IDsOMIM: 601877; MGI: 2443573; GeneCards: LEFTY2
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

7044

320202

Ensembl

ENSG00000143768

ENSMUSG00000066652

UniProt

O00292

P57785

RefSeq (mRNA)

NM_001172425
NM_003240

NM_177099

RefSeq (protein)

NP_001165896
NP_003231

NP_796073

Location (UCSC)Chr 1: 225.94 – 225.94 MbChr 1: 180.72 – 180.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Left-right determination factor 2 (Lefty2) aka TGFB4 is a protein that is encoded by the LEFTY2 gene in humans.[5]

Function

Lefty2 is a protein from the TGF-beta cytokine family of proteins and is sometimes referred to as TGFB-4.[6][7] It is secreted and plays a role in left-right asymmetry determination of organ systems during development. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs.

Lefty2 is also sometimes referred to as Endometrial Bleeding-Associated Factor (EBAF).[6] Some types of infertility have been associated with dysregulated expression of this gene in the endometrium and the protein may play a role in endometrial bleeding.

Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143768 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000066652 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Left-right determination factor 2". Retrieved 2016-04-19.
  6. ^ a b GeneCards Human Gene Database. "LEFTY2 Gene - GeneCards | LFTY2 Protein | LFTY2 Antibody". www.genecards.org. Archived from the original on 2021-12-15. Retrieved 2025-04-03.
  7. ^ "LEFTY2 left-right determination factor 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2025-04-03.

Further reading

  • Tabibzadeh S, Kothapalli R, Buyuksal I (1997). "Distinct tumor specific expression of TGFB4 (ebaf)*, a novel human gene of the TGF-beta superfamily". Front. Biosci. 2: a18–25. doi:10.2741/a158. PMID 9230066.


This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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