Large cell neuroendocrine carcinoma of the lung

Large-cell neuroendocrine carcinoma of the lung (LCNEC of the lung), or pulmonary large-cell neuroendocrine carcinoma (PLCNC), is a highly malignant neoplasm arising from transformed epithelial cells originating in tissues within the pulmonary tree. It is currently considered to be a subtype of large-cell lung carcinoma.

LCNEC is often generically grouped among the non-small-cell lung carcinomas.^[1]

LCNECs often have inactivations of p53 and RB (~40%), or inactivation of TP53 and STK11 or KEAP1 (~40%).^[2]

Variants

The World Health Organization classification of lung tumors^[1] recognizes a variant of LCNEC, namely "combined large-cell neuroendocrine carcinoma" (c-LCNEC).

References

1. Travis, William D; Brambilla, Elisabeth; Muller-Hermelink, H Konrad; et al., eds. (2004). Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart (PDF). World Health Organization Classification of Tumours. Lyon: IARC Press. ISBN 978-92-832-2418-1. Archived from the original (PDF) on 23 August 2009. Retrieved 27 March 2010.
2. George; Walter; Peifer; Alexandrov; et al. (2018). "Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors". Nature Communications. 9 (Article number: 1048): 1048. Bibcode:2018NatCo...9.1048G. doi:10.1038/s41467-018-03099-x. PMC 5849599. PMID 29535388.

External links

• Lung Cancer Home Page. The National Cancer Institute site containing further reading and resources about lung cancer.
• [1]. World Health Organization Histological Classification of Lung and Pleural Tumours. 4th Edition.