LIN7B

LIN7B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DKR
Identifiers
Aliases	LIN7B, LIN-7B, MALS-2, MALS2, VELI2, lin-7 homolog B, crumbs cell polarity complex component
External IDs	OMIM: 612331; MGI: 1330858; HomoloGene: 22648; GeneCards: LIN7B; OMA:LIN7B - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 49,114,324 bp[1] End 49,118,460 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 45,017,315 bp[2] End 45,020,007 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior cingulate cortex endothelial cell right frontal lobe nucleus accumbens Brodmann area 9 anterior pituitary prefrontal cortex Amygdala caudate nucleus putamen Top expressed in facial motor nucleus motor neuron superior frontal gyrus dentate gyrus of hippocampal formation granule cell primary visual cortex substantia nigra barrel cortex primary motor cortex anterior amygdaloid area Region I of hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding protein domain specific binding L27 domain binding protein binding Cellular component postsynaptic membrane postsynaptic density membrane cell-cell junction bicellular tight junction plasma membrane cell junction basolateral plasma membrane neuron projection presynapse synapse MPP7-DLG1-LIN7 complex Biological process protein localization to basolateral plasma membrane maintenance of epithelial cell apical/basal polarity protein transport neurotransmitter secretion exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64130 22342 Ensembl ENSG00000104863 ENSMUSG00000003872 UniProt Q9HAP6 O88951 RefSeq (mRNA) NM_001308419 NM_022165 NM_011698 RefSeq (protein) NP_001295348 NP_071448 NP_035828 Location (UCSC) Chr 19: 49.11 – 49.12 Mb Chr 7: 45.02 – 45.02 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Lin-7 homolog B is a protein that in humans is encoded by the LIN7B gene.^[5][6]

Interactions

LIN7B has been shown to interact with:

• ACCN3,^[7]
• GRIN2B,^[5]
• KCNJ12^[8][9] and
• KCNJ4.^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000104863 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003872 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jo K, Derin R, Li M, Bredt DS (Jun 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci. 19 (11): 4189–99. doi:10.1523/JNEUROSCI.19-11-04189.1999. PMC 6782594. PMID 10341223.
6. "Entrez Gene: LIN7B lin-7 homolog B (C. elegans)".
7. Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ (Nov 2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current". J. Biol. Chem. 279 (45): 46962–8. doi:10.1074/jbc.M405874200. PMID 15317815.
8. Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.
9. Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (Apr 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
10. Olsen O, Liu H, Wade JB, Merot J, Welling PA (Jan 2002). "Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex". Am. J. Physiol., Cell Physiol. 282 (1): C183-95. doi:10.1152/ajpcell.00249.2001. PMID 11742811.

Further reading

• Butz S, Okamoto M, Südhof TC (1998). "A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain". Cell. 94 (6): 773–82. doi:10.1016/S0092-8674(00)81736-5. PMID 9753324. S2CID 12465062.
• Olsen O, Liu H, Wade JB, Merot J, Welling PA (2002). "Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex". Am. J. Physiol., Cell Physiol. 282 (1): C183–95. doi:10.1152/ajpcell.00249.2001. PMID 11742811.
• Coussen F, Normand E, Marchal C, Costet P, Choquet D, Lambert M, Mège RM, Mulle C (2002). "Recruitment of the kainate receptor subunit glutamate receptor 6 by cadherin/catenin complexes". J. Neurosci. 22 (15): 6426–36. doi:10.1523/JNEUROSCI.22-15-06426.2002. PMC 6758172. PMID 12151522.
• Hori K, Konno D, Maruoka H, Sobue K (2003). "MALS is a binding partner of IRSp53 at cell-cell contacts". FEBS Lett. 554 (1–2): 30–4. doi:10.1016/S0014-5793(03)01074-3. PMID 14596909. S2CID 30329043.
• Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
• Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.
• Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ (2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current". J. Biol. Chem. 279 (45): 46962–8. doi:10.1074/jbc.M405874200. PMID 15317815.
• Okuhira K, Fitzgerald ML, Sarracino DA, Manning JJ, Bell SA, Goss JL, Freeman MW (2006). "Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux". J. Biol. Chem. 280 (47): 39653–64. doi:10.1074/jbc.M510187200. PMID 16192269.
• Kawai S, Fukuda C, Mukai T, Murata K (2006). "MJ0917 in archaeon Methanococcus jannaschii is a novel NADP phosphatase/NAD kinase". J. Biol. Chem. 280 (47): 39200–7. doi:10.1074/jbc.M506426200. PMID 16192277.
• Li Z, Benard O, Margolskee RF (2006). "Ggamma13 interacts with PDZ domain-containing proteins". J. Biol. Chem. 281 (16): 11066–73. doi:10.1074/jbc.M600113200. PMID 16473877.
• Sudo K, Ito H, Iwamoto I, Morishita R, Asano T, Nagata K (2007). "Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons". Neurosci. Res. 56 (4): 347–55. doi:10.1016/j.neures.2006.08.003. PMID 16979770. S2CID 45834664.