L-olivosyl-oleandolide 3-O-methyltransferase

L-olivosyl-oleandolide 3-O-methyltransferase
Identifiers
EC no.	2.1.1.239
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

L-olivosyl-oleandolide 3-O-methyltransferase (EC 2.1.1.239, OleY) is an enzyme with systematic name S-adenosyl-L-methionine:L-olivosyl-oleandolide B 3-O-methyltransferase.^[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + L-olivosyl-oleandolide ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + L-oleandrosyl-oleandolide

The enzyme is involved in the biosynthesis of the macrolide antibiotic oleandomycin in Streptomyces antibioticus.

References

1. Rodríguez L, Rodríguez D, Olano C, Braña AF, Méndez C, Salas JA (September 2001). "Functional analysis of OleY L-oleandrosyl 3-O-methyltransferase of the oleandomycin biosynthetic pathway in Streptomyces antibioticus". Journal of Bacteriology. 183 (18): 5358–63. doi:10.1128/jb.183.18.5358-5363.2001. PMC 95419. PMID 11514520.

External links

• L-olivosyl-oleandolide+3-O-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)