L-lysine 6-oxidase

L-lysine 6-oxidase
Identifiers
EC no.	1.4.3.20
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

In enzymology, a L-lysine 6-oxidase (EC 1.4.3.20) is an enzyme that catalyzes the chemical reaction

L-lysine + O₂ + H₂O ${\displaystyle \rightleftharpoons }$ 2-aminoadipate 6-semialdehyde + H₂O₂ + NH₃

The 3 substrates of this enzyme are L-lysine, O₂, and H₂O, whereas its 3 products are 2-aminoadipate 6-semialdehyde, H₂O₂, and NH₃.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with oxygen as acceptor. The systematic name of this enzyme class is L-lysine:oxygen 6-oxidoreductase (deaminating). Other names in common use include L-lysine-epsilon-oxidase, Lod, LodA, and marinocine.

References

• Lucas-Elio P, Gomez D, Solano F, Sanchez-Amat A (2006). "The antimicrobial activity of marinocine, synthesized by Marinomonas mediterranea, is due to hydrogen peroxide generated by its lysine oxidase activity". J. Bacteriol. 188 (7): 2493–501. doi:10.1128/JB.188.7.2493-2501.2006. PMC 1428416. PMID 16547036.
• Gomez D, Lucas-Elio P, Sanchez-Amat A, Solano F (2006). "A novel type of lysine oxidase: L-lysine-epsilon-oxidase". Biochim. Biophys. Acta. 1764 (10): 1577–85. doi:10.1016/j.bbapap.2006.08.014. PMID 17030025.